Publications by authors named "Aman Mehan"
Importance: Whether patients with Child-Pugh class B (CP-B) cancer with unresectable hepatocellular carcinoma (uHCC) benefit from active anticancer treatment vs best supportive care (BSC) is debated.
Objective: To evaluate the association of immune checkpoint inhibitor (ICI)-based therapies vs BSC with overall survival (OS) of patients with uHCC and CP-B liver dysfunction.
Design, Setting, And Participants: This retrospective, multicenter, international clinical case series examined data of patients with CP-B with uHCC who were receiving first-line ICI-based regimens from September 2017 to December 2022 whose data were extracted from an international consortium and compared with a cohort of patients with CP-B receiving BSC.
Article Synopsis
- The Hammersmith Score (HS) is a validated prognostic tool that helps predict response and survival rates in early-phase cancer trial participants based on routine biochemical measures.
- A study analyzed 212 patient referrals, finding that HS significantly predicted overall survival and outperformed the Royal Marsden Score (RMS) in its predictive ability.
- HS offers a simple and cost-effective method to improve patient selection and referral for early-phase cancer trials, especially in the context of modern cancer immunotherapy.
Introduction: Identifying which patient may benefit from immunotherapeutic early-phase clinical trials is an unmet need in drug development. Among several proposed prognostic scores, none has been validated in patients receiving immunomodulating agents (IMAs)-based combinations.
Patients And Methods: We retrospectively collected data of 208 patients enrolled in early-phase clinical trials investigating IMAs at our Institution, correlating clinical and blood-based variables with overall survival (OS).
Opioids are a commonly prescribed and efficacious medication for the treatment of chronic pain but major side effects such as addiction, respiratory depression, analgesic tolerance, and paradoxical pain hypersensitivity make them inadequate and unsafe for patients requiring long-term pain management. This review summarizes recent advances in our understanding of the outcomes of chronic opioid administration to lay the foundation for the development of novel pharmacological strategies that attenuate opioid tolerance and hypersensitivity; the two main physiological mechanisms underlying the inadequacies of current therapeutic strategies. We also explore mechanistic similarities between the development of neuropathic pain states, opioid tolerance, and hypersensitivity which may explain opioids' lack of efficacy in certain patients.
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- Calanolides are a group of compounds known for their anti-HIV-1 activity, particularly Calanolide A, which inhibits reverse transcriptase and is classified as a non-nucleoside reverse transcriptase inhibitor (NNRTI).
- There are at least 15 naturally occurring calanolides, mainly from specific plant genera, which also show potential in treating cancer, antimicrobial, and antiparasitic conditions.
- The review article provides an in-depth overview of calanolides, covering their chemistry, natural occurrence, how they are made, their pharmacological and toxicological effects, mechanisms of action, and related patents.
COVID-19: should oral vaccination strategies be given more consideration?
Ther Adv Vaccines Immunother
July 2020