An experimental study on lung deposition of inhaled 2 μm particles in relation to lung characteristics and deposition models.

Background: The understanding of inhaled particle respiratory tract deposition is a key link to understand the health effects of particles or the efficiency for medical drug delivery via the lung. However, there are few experimental data on particle respiratory tract deposition, and the existing data deviates considerably when comparing results for particles > 1 μm.

Methods: We designed an experimental set-up to measure deposition in the respiratory tract for particles > 1 μm, more specifically 2.