Linear and Polyvalent Peptides with Potent Antimicrobial Activity Against Sensitive and Multidrug-Resistant E. c oli Clinical Isolates.

Peptides containing the sequences RRWQWR and RRWQWRMKKLG derived from Bovine lactoferricin (LfcinB) were synthesized and their antibacterial effect against reference strains and sensitive and resistant clinical isolates of E. coli was evaluated. Tetra-branched multiple antigen peptide (MAP) ((RRWQWR)-K-Ahx-C) exhibited significant antibacterial activity against sensitive, resistant, and multidrug-resistant clinical isolates of E.