Publications by authors named "Amaldev Karunakaran"
Article Synopsis
- HBeAg is an important marker for evaluating hepatitis B virus replication and its reliability in testing was assessed using standard methods and clinical samples.
- Performance analyses of several enzyme immunoassays showed significant differences in their sensitivity and antibody affinity.
- The variations in antibody affinity may affect the accuracy and reliability of HBeAg tests used for diagnosing and managing hepatitis B.
Background & Aim: Hepatitis B virus-e-antigen (HBeAg) is an affordable viral marker to assess viral replication kinetics and response to antiviral therapy. In the absence of confirmatory assays, discrepant or false-positive HBeAg results are resolved by screening for other HBV markers. We standardized an in-house HBeAg neutralization assay (HBeAg-NT) to confirm HBeAg in clinical samples.
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