Design, Synthesis, and Biological Evaluation of Newly Synthesized Cinnamide-Fluorinated Containing Compounds as Bioactive Anticancer Agents.

A new series of cinnamide-fluorinated derivatives has been synthesized and characterized by using different spectroscopic and elemental microanalyses methods. All of the prepared -fluorocinnamide derivatives were evaluated for their cytotoxic activity against the HepG2 liver cancerous cell line. The imidazolone derivative , which bears -(-pyrimidin-2-ylbenzenesulphamoyl) moiety, displayed antiproliferative activity against HepG2 liver cancerous cells with an IC value of 4.

Sucrose esters of aryldihydronaphthalene-type lignans, and antitumor activity of extracts of (Forssk.) aerial parts.

One new compound 3f-[(7',8')-4,4'-dihydroxy-5-methoxy-2,7'-cycloligna-7-en-9-methoxycarbonyl, 9'-carbonyl--] -- D-fructofuranosyl- (→)-- D-glucopyranoside) (Moltkiopsin A) was isolated and identified from the extract of aerial parts of the wild Egyptian plant (Frossk.), family Boraginaceae, for the first time, along with two aryldihydronaphthalene lignans 3f→9':6f→9-[(7',8')-4,4'- dihydroxy-3,3',5-trimethoxy-2,7'-cycloligna-7-en-9,9'-dicarbonyl]-6g-acetyl--D-gluco pyranosyl-(→) --D-fructofuranoside (Trigonotin A) which was reported for the first time from this plant species and a known compound 3f→9':6f→9-[(7',8')-4,4'- dihydroxy-3,3',5-trimethoxy-2,7'-cycloligna-7-en-9,9'-dicarbonyl]--D-gluco pyranosyl - (→)- -D- fructofuranoside (Trigonotin C) . These compounds were separated and purified using different chromatographic techniques and their structures were elucidated by extensive 1D (H and C NMR), and 2D NMR (COSY, HSQC, and HMBC), besides ESI-MS spectral methods.

The Effect of Iron Oxide Nanoparticles of Ethyl Acetate Extract on Ehrlich Ascites Carcinoma Cells.

Background: Nanoparticles' precise targeting properties are becoming increasingly important in treating cancer and starting to outweigh cancer therapies.

Methods: The anticancer activity of ethyl acetate iron oxide nanoparticles (NP EAE) of Müll. Mosaica was tested using Ehrlich ascites carcinoma cells (EAC).