Publications by authors named "Amal M Yahya"
Article Synopsis
- - A young male infant with X-linked severe combined immunodeficiency was identified with a new genetic variant linked to interleukin 2 receptor and developed serious health issues after receiving the BCG vaccine.
- - The case raises concerns about the early administration of live vaccines like BCG in infants with underlying immunodeficiencies and suggests that such variants might be related to a specific type of disease susceptibility.
- - The infant exhibited symptoms resembling hemophagocytic lymphohistiocytosis (HLH) without typical markers, prompting a call to reconsider HLH diagnostic criteria to include conditions causing a lack of systemic inflammation.
Fermitin family homolog 3 (FERMT3), alternatively kindlin-3 (KIND3), is an integrin binding protein (of 667 residues) encoded by the gene. The molecule is essential for activating integrin αβ (the fibrinogen receptor) on platelets and for the integrin-mediated hematopoietic cell (including platelets, T lymphocytes, B lymphocytes, and granulocytes) adhesion. Its defects are associated with impaired primary hemostasis, described as "Glanzmann's thrombasthenia (MIM#273800)-like bleeding problem.
View Article and Find Full Text PDFIn the United Arab Emirates, BCG (Bacillus Calmette-Guérin) is administered to all newborns. We present here a young infant with an inborn error of immunity (IEI) who developed fatal adverse events to this live-attenuated vaccine. This male infant received BCG (Serum Institute of India Pvt.
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