Publications by authors named "Amal Alrashidi"
This study assessed the Raedwoon program, a 25-day nursing leadership course, using a quasi-experimental design. It found overall improvements in leadership and nursing competencies, except in the “Inspire a Shared Vision” practice and documentation skills.
View Article and Find Full Text PDFCeftriaxone sodium belongs to the third-generation cephalosporin group and is used intramuscular and intravenous route as a broad-spectrum antibiotic. This research aims to prepare biocompatible hydrogels for targeted delivery of ceftriaxone sodium by parental route. Different proportions of polymers (natural and synthetic) in the presence of cross-linker were synthesized by solvent casting method.
View Article and Find Full Text PDFFabrication of Nanocrystals for Enhanced Distribution of a Fatty Acid Synthase Inhibitor (Orlistat) as a Promising Method to Relieve Solid Ehrlich Carcinoma-Induced Hepatic Damage in Mice.
Pharmaceuticals (Basel)
January 2024
Article Synopsis
- Orlistat (ORL) is a lipase inhibitor with anticancer properties, but its low solubility limits its effectiveness; this study aimed to enhance its solubility and absorption by creating nanocrystals (NCs).
- The nanocrystals were successfully prepared, resulting in significantly better solubility and a remarkable 258.70% increase in relative bioavailability compared to standard ORL forms, as confirmed by animal studies.
- In vivo results indicated that ORL-NC reduced liver function indicators associated with damage and showed improvements in liver tissue, suggesting that this formulation could effectively enhance ORL's therapeutic potential and reduce liver damage from cancer.
There is a need for new antimicrobial systems due to increased global resistance to current antimicrobials. Pomegranate rind extract (PRE) and Zn (II) ions both possess a level of antimicrobial activity and work has previously shown that PRE/Zn (II) in combination possesses synergistic activity against virus and . Here, we determined whether such synergistic activity extended to other, more pathogenic, bacteria.
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