Publications by authors named "Amaia Setien-Olarra"
Genetic polymorphisms of inflammatory and bone metabolism related proteins in a population with dental implants of the Basque Country. A case-control study.
BMC Oral Health
June 2024
Background: Peri-implantitis (PI) is a frequent inflammatory disorder characterised by progressive loss of the supporting bone. Not all patients with recognised risk factors develop PI. The aim of this study is to evaluate the presence of single nucleotide polymorphisms (SNP) of inflammatory and bone metabolism related proteins in a population treated with dental implants from the Basque Country (Spain).
View Article and Find Full Text PDFPurpose: To perform a systematic review and meta-analysis on the presence of inflammatory polymorphisms in patients with peri-implantitis (PI). PI is the main complication associated to dental implant therapy. Although its main risk factors are history of periodontitis, poor plaque control and lack of regular maintenance, genetic susceptibility could also be a determinant factor for its appearance.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to explore the link between TLR (Toll-like receptor) genetic variations and the risk of head and neck cancers, specifically focusing on oral squamous cell carcinoma (OSCC), laryngeal squamous cell carcinoma (LSCC), and oral potentially malignant disorders like oral lichen planus (OLP) and oral lichenoid lesions (OLL).
- - It included a group of 40 OSCC patients, 35 LSCC patients, 175 OLD patients, and 89 healthy controls from the Basque Country, Spain, and used genetic testing to analyze TLR polymorphisms.
- - The findings indicated that the TLR2-rs4696480 variant significantly elevated the risk of OSCC and
Background: The Basque Country has one of the highest rates of head and neck squamous cell carcinoma (HNSCC) in Europe, although tobacco and alcohol consumption are not high when compared to other European countries where HNSCC incidence is lower. Our aim was to determine the role of genetic variation with regard to the metabolism of alcohol and carcinogens from tobacco smoke in the Basque Country.
Methods: Fourteen polymorphisms in alcohol or tobacco metabolism genes were genotyped in 84 HNSCC patients and 242 healthy individuals from the Basque Country.