Publications by authors named "Amadeo Ten-Steve"
Intratumoral injection of melatonin enhances tumor regression in cell line-derived and patient-derived xenografts of head and neck cancer by increasing mitochondrial oxidative stress.
Laura Martinez-Ruiz Javier Florido César Rodriguez-Santana Alba López-Rodríguez Ana Guerra-Librero Amadeo Ten-Steve
Biomed Pharmacother
November 2023
Article Synopsis
- Head and neck squamous cell carcinoma (HNSCC) has a high mortality rate, prompting the need for effective treatments, such as melatonin, which has shown potential in cancer therapy.
- This study investigates the optimal administration of melatonin, comparing subcutaneous and intratumoral injections in various tumor models, revealing that intratumoral injections significantly inhibit tumor growth and enhance the effects of cisplatin.
- Findings indicate that intratumoral melatonin boosts reactive oxygen species production and apoptosis while reducing tumor migration and metastasis, highlighting its promise for future clinical applications in cancer treatment.