Publications by authors named "Alzbeta Cardova"
Article Synopsis
- - Chronic wasting disease (CWD) is a deadly prion disease affecting deer, elk, and other cervids, leading to environmental contamination and transmission among these animals.
- - Research is focused on cervid breeding programs to enhance genetic resistance to CWD, involving the examination of prion protein (PrP) variants that could decrease the disease burden and potential human health risks.
- - Scientists have created genetically modified fruit flies (Drosophila) expressing different cervid PrP variants to study their susceptibility to prion infections, finding that certain variants (N138) show slower accumulation of prion activity compared to others (S138), making these flies a useful model for CWD research.
Inherited human prion diseases, such as fatal familial insomnia (FFI) and familial Creutzfeldt-Jakob disease (fCJD), are associated with autosomal dominant mutations in the human prion protein gene and accumulation of PrP, an abnormal isomer of the normal host protein PrP, in the brain of affected individuals. PrP is the principal component of the transmissible neurotoxic prion agent. It is important to identify molecular pathways and cellular processes that regulate prion formation and prion-induced neurotoxicity.
View Article and Find Full Text PDFThe prion protein (PrP) can be structurally shifted to its PrP isoform causing a wide range of neurodegenerative diseases, which are currently incurable. There is an evidence that metallothioneins (MTs), and especially MT-3, are associated with neurodegenerative diseases. PrP and MTs play pivotal roles in maintaining metal homeostasis; therefore, it is conceivable that each of them has its own significance in prion diseases.
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