Publications by authors named "Alyssa Veneziale"
Objective: Articular cartilage exists in a hypoxic environment, which motivates the use of hypoxia-simulating chemical agents to improve matrix production in cartilage tissue engineering. The aim of this study was to investigate whether dimethyloxalylglycine (DMOG), a HIF-1α stabilizer, would improve matrix production in 3-dimensional (3D) porcine synovial-derived mesenchymal stem cell (SYN-MSC) co-culture with chondrocytes.
Design: Pellet cultures and scaffold-based engineered cartilage were grown to determine the impact of chemically simulated hypoxia on 2 types of 3D cell culture.