Reversal of obesity development in Ceacam1 male mice by bone marrow transplantation or introduction of the human CEACAM1 gene.

Objective: Although Ceacam1 male mice become obese on normal chow, the effect of bone marrow transplantation or introduction of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) gene has not been studied, to the knowledge of the authors.

Methods: This study analyzed Ceacam1 mice on normal diet or high-fat diet (HFD), including effects of bone marrow transplantation or introduction of the CEACAM1 gene.

Results: Male Ceacam1 mice on normal diet versus HFD for 24 weeks gained significantly more weight than controls, and Ceacam1 mice aged up to 2 years had a high frequency of liver cancer.

Role of lncRNA LIPE-AS1 in adipogenesis.

Recent studies have identified long non-coding RNAs (lncRNAs) as potential regulators of adipogenesis. In this study, we have characterized a lncRNA, LIPE-AS1, that spans genes to in man with conservation of genomic organization and tissue expression between mouse and man. Tissue-specific expression of isoforms of the murine lncRNA were found in liver and adipose tissue, one of which, designated mLas-V3, overlapped the gene encoding hormone-sensitive lipase in both mouse and man suggesting that it may have a functional role in adipose tissue.