Haploinsufficiency of in Mice Selectively Impairs Target Odor Recognition in Novel Background Odors.

Individuals with mutations in a single copy of the SHANK3 gene present with social interaction deficits. Although social behavior in mice depends on olfaction, mice with mutations in a single copy of the gene do not have olfactory deficits in simple odor identification tasks (Drapeau et al., 2018).