Synopsis of recent research by authors named "Alyssa N Ho"
- Alyssa N Ho's recent research primarily focuses on the metabolic mechanisms underlying breast cancer progression and treatment responses, particularly in triple-negative breast cancer (TNBC) and the role of hypoxia in immunosuppression.
- She has identified hypoxia-mediated repression of pyruvate carboxylase as a critical metabolic regulator that influences lactate production, detrimental to immune responses against tumors.
- Additionally, her work explores therapeutic strategies, such as exogenous metabolic modulators and tirzepatide, which demonstrate potential in enhancing chemotherapy efficacy and reducing tumor growth, especially in obese cancer models.
