Publications by authors named "Alyssa N Colyer"
J Cell Mol Immunol
January 2023
Article Synopsis
- Systemic lupus erythematosus (SLE) is an autoimmune disease where the body produces autoantibodies against its own proteins, particularly targeting ORF1p from the LINE-1 element.
- In a study, SLE patients showed higher levels of IgG autoantibodies against several proteins, including RO60 and others that interact with ORF1p, compared to healthy individuals.
- These specific autoantibodies were linked to more severe disease activity and elevated type I interferon levels, suggesting that the immune response in SLE may target RNA-rich granules containing ORF1p.
