Publications by authors named "Alyssa Lutservitz"
Human brains vary across people and over time; such variation is not yet understood in cellular terms. Here we describe a relationship between people's cortical neurons and cortical astrocytes. We used single-nucleus RNA sequencing to analyse the prefrontal cortex of 191 human donors aged 22-97 years, including healthy individuals and people with schizophrenia.
View Article and Find Full Text PDFHuman brains vary across people and over time; such variation is not yet understood in cellular terms. Here we describe a striking relationship between people's cortical neurons and cortical astrocytes. We used single-nucleus RNA-seq to analyze the prefrontal cortex of 191 human donors ages 22-97 years, including healthy individuals and persons with schizophrenia.
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- Chimerism is more common in marmosets and tamarins due to their fraternal twin or triplet birth patterns, which lead to persistent blood chimerism throughout life.
- Analysis of marmoset tissue showed that sibling-derived chimerism only originated from blood-derived cells, particularly affecting microglia and macrophages in the brain.
- This natural occurrence of chimerism in marmosets offers insights into gene and mutation effects on microglial biology and helps differentiate their roles from other cell types in brain functions.
Article Synopsis
- Researchers examined over 2.4 million brain cells from 18 locations in the common marmoset using single-nucleus RNA sequencing to analyze gene expression patterns in various brain structures.
- The findings suggest that the adult identity of most neuron types is influenced more by their developmental origins than by the types of neurotransmitters they release.
- High proportions of specific neuron types were found in higher-order cortical areas, and the study utilized cell type-specific enhancers and AAV-GFP to visualize different interneuron morphologies in the neocortex and striatum.
Article Synopsis
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Neurogenesis is now known to play a role in adult hypothalamic function, yet the cell-cell mechanisms regulating this neurogenesis remain poorly understood. Here, we show that Hedgehog (Hh)/Gli signaling positively regulates hypothalamic neurogenesis in both larval and adult zebrafish and is necessary and sufficient for normal hypothalamic proliferation rates. Hh-responsive radial glia represent a relatively highly proliferative precursor population that gives rise to dopaminergic, serotonergic, and GABAergic neurons.
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- A study examined the RNA expression of almost 190,000 individual interneurons from three types of primates (human, macaque, and marmoset), a mouse, and a ferret to understand the cellular basis of behavioral and cognitive differences stemming from a common ancestor.
- The findings revealed significant variations in interneuron types and gene expression between rodents and primates, while primates showed less diversity among themselves.
- Notably, a specific interneuron subtype, the "ivy cell," was found to be abundant in primates but absent in rodents, along with a unique striatal interneuron type in primates featuring distinct gene expressions, suggesting evolutionary adaptations in brain structure and function.