In-line monitoring of Ibuprofen during and after tablet compression using near-infrared spectroscopy.

Near infrared spectroscopy (NIRS) used as process analytical technology tool to monitor Active Pharmaceutical Ingredient concentrations during tablet manufacturing has been reported to enhance overall product quality assurance. NIRS applications in different manufacturing stages are facilitated by their ability to handle different sample presentations - be it solids, liquids, gels or powders. The present study evaluates NIRS suitability for monitoring Ibuprofen concentrations (coated pellets form) inside the feed frame of a tableting press as well as in output tablets.