Discovery of the Lipopeptides Albubactins A-H from RKJM0023 via Chemical Elicitation with Rhamnolipids and Synthesis of Albubactin A.

The marine tunicate-derived RKJM0023 was cultured in the presence of a rhamnolipid mixture in an effort to elicit the production of silent natural products. MS/MS-based molecular networking analysis enhanced with nonparametric statistics highlighted the upregulation of a molecular cluster (Kruskal-Wallis = 1.6 e for ) in which no MS/MS features had library matches.

Discovery of Levesquamide B through Global Natural Product Social Molecular Networking.

Levesquamide A is an isothiazolinone-containing anti-tubercular natural product isolated from sp. RKND-216. Through the use of Global Natural Product Social Molecular Networking (GNPS), additional members of the levesquamide family were identified (B-G).

Draft Genome Sequence of sp. Strain RKCA744, Isolated from the Arauca River, Colombia.

sp. strain RKCA744 was isolated from sediment collected from the Arauca River, Colombia.

Auyuittuqamides A-D, Cyclic Decapeptides from RKAG 186 Isolated from Frobisher Bay Sediment.

Four new cyclic decapeptides, auyuittuqamides A-D (-), were obtained from RKAG 186 obtained from marine sediment collected from the intertidal zone of Frobisher Bay, Nunavut, Canada. The structures of the compounds were elucidated by NMR spectroscopy and tandem mass spectrometry. The absolute configurations of the amino acids were determined using Marfey's method.

Mortiamides A-D, Cyclic Heptapeptides from a Novel Mortierella sp. Obtained from Frobisher Bay.

Four new cyclic heptapeptides, mortiamides A-D (1-4), were obtained from a novel Mortierella sp. isolate obtained from marine sediment collected from the intertidal zone of Frobisher Bay, Nunavut, Canada. The structures of the compounds were elucidated by NMR spectroscopy and tandem mass spectrometry.