Long-acting injectable methadone (methadone-fluconazole) provides safe and effective postoperative analgesia in a randomized clinical trial for dogs undergoing soft tissue surgery.

Objective: To assess the pharmacokinetics, clinical efficacy, and adverse effects of injectable methadone with the pharmacokinetic enhancer fluconazole (methadone-fluconazole), compared with the standard formulation of injectable methadone, in dogs after ovariohysterectomy. We hypothesized that 2 doses of methadone-fluconazole would provide 24 hours of postoperative analgesia.

Animals: 3 purpose-bred dogs (pharmacokinetic preliminary study) and 42 female dogs from local shelters (clinical trial) were included.

Evaluation of Contamination of Multiuse Suture Cassettes in an HQHVSN Environment.

Historically, it has been thought that suture cassettes become contaminated by bacteria through multiuse. However, High-Quality, High-Volume Spay/Neuter (HQHVSN) veterinarians have been using them for years without issue because of their significantly lower cost. The objective of this study was to determine if absorbable suture cassettes are contaminated through multiuse in an HQHVSN environment.