Publications by authors named "Alyssa Ehrlich"
Objective: To provide additional information about clinical features associated with adult ADHD in patients diagnosed in childhood compared to those first diagnosed in adulthood.
Method: We stratified a sample of adults with ADHD into patients diagnosed in childhood versus adulthood and compared demographic and clinical characteristics.
Results: We found similar clinical features in adults diagnosed in childhood and adults diagnosed in adulthood.
Article Synopsis
- A comprehensive study identified over 11,000 circular RNAs (circRNAs) in specific brain cells from 190 human brains, focusing on vulnerable dopamine and pyramidal neurons using advanced RNA sequencing.
- A significant number of these circRNAs are specific to the types of neurons and are linked to synaptic pathways, suggesting a role in brain function and diseases.
- The findings indicate that certain circRNAs are connected to neuropsychiatric conditions, with particular genes linked to Parkinson's and Alzheimer's producing distinct circRNAs, underscoring their potential role in neuronal identity and disease mechanisms.
Article Synopsis
- The study identified over 11,039 circular RNAs (circRNAs) in specific brain cells, focusing on dopamine and pyramidal neurons from human brains, highlighting their potential role in neuropsychiatric diseases.
- A significant number of circRNAs were found to be specific to dopamine and pyramidal neurons, with a notable enrichment in synaptic pathways relevant to disorders like Parkinson's and Alzheimer's.
- The research reveals that circRNAs are produced differently depending on the neuron type, linking their expression to various neuropsychiatric conditions, such as addiction and autism, suggesting circRNAs regulate synaptic specialization in these diseases.
Emerging data highlight the critical role for the innate immune system in the progression of nonalcoholic fatty liver disease (NAFLD). Connexin 32 (Cx32), the primary liver gap junction protein, is capable of modulating hepatic innate immune responses and has been studied in dietary animal models of steatohepatitis. In this work, we sought to determine the association of hepatic Cx32 with the stages of human NAFLD in a histologically characterized cohort of 362 patients with NAFLD.
View Article and Find Full Text PDFPurpose: To determine the extent to which the 24-2 visual field (VF) misses macular damage confirmed with both 10-2 VF and optical coherence tomography (OCT) tests and to evaluate the patterns of damage missed.
Methods: One hundred forty-one eyes of 141 glaucoma patients or suspects underwent 24-2 VF (mean deviation [MD] better than -6 dB), 10-2 VF, and OCT testing. Retinal nerve fiber layer (RNFL) and retinal ganglion cell plus inner plexiform (RGC+) probability plots were combined with 10-2 VF probability plots.
Purpose: To simulate modified versions of the 24-2 (6° grid) visual field (VF) test pattern by adding points from the 10-2 (2° grid) test pattern, and to assess their ability to detect early glaucomatous defects in the central 10°.
Methods: One hundred forty-four eyes of 144 glaucoma patients and suspects with 24-2 mean deviations better than -6 dB were tested with 10-2 and 24-2 VFs. Based upon both 10-2 VF and optical coherence tomography probability plots, 63 hemifields were defined as abnormal, while 121 hemifields were defined as normal.
Purpose: To use high-density perimetry to test a model of local glaucomatous damage to the macula (central visual field [VF]) and to assess the optimal placement of stimuli used to detect this damage
Methods: Thirty-one eyes of 31 patients showing glaucomatous arcuate damage within the upper hemifield of the central 10° were tested with a customized VF with double the density of the 10-2 (2° grid) test. Individual plots of total deviation (TD) values were generated. A model, which predicts a "vulnerable macular region" (VMR) and a "less vulnerable macular region" (LVMR), was compared with the TD values without (standard model) and with (aligned model) scaling and rotating to align it with the patient's fovea-to-disc axis.