Functional Characteristics of the Mouse Promoter in Various Tissues Before and After Irradiation.

Interleukin-1 beta () is a key inducer of inflammation and an important factor in the regulation of hematopoietic stem cells and mesenchymal stromal progenitors. Irradiation of mice with ionizing radiation has been shown to induce a lasting increase in IL1B concentration in peripheral blood. One of the possible mechanisms may be demethylation of CpG cytosines in the promoter, which has not been characterized in detail for the mouse.