Publications by authors named "Aly Abdelkareem"
Article Synopsis
- Understanding the diffuse invasion of glioblastoma cells is crucial for addressing tumor aggressiveness and resistance to treatment, which negatively impacts patient prognosis.
- The study utilizes a novel computational method to analyze GBM xenografts, distinguishing human tumor cells from the mouse tumor microenvironment (TME), resulting in a detailed overview of 15 tumor cell programs linked to invasion pathways.
- The findings suggest targeted interventions on tumor and TME components could lead to improved therapies by revealing compensatory mechanisms that might aid in developing more effective combination treatments.
Article Synopsis
- - The study explored how the 3D structure of the genome influences the functional traits of glioblastoma stem cells (GSCs), using high-resolution DNA mapping techniques to reveal differences in genome architectures among patients.
- - The research found that variations in DNA looping and chromatin organization contribute to the heterogeneity of glioblastoma and help regulate gene expression, highlighting that specific stemness genes serve as interaction hubs for multiple regulatory elements.
- - The findings suggest that certain regions of open chromatin in GSCs are linked to immune-related gene expression and indicate that targeting specific genes like CD276 could help eliminate self-renewing cancer cells, promoting new therapeutic approaches.
