Publications by authors named "Alwin M Graf"
Article Synopsis
- Axolotls can regrow their limbs, and a special group of cells called "senescent cells" helps this process by creating a supportive environment for new cells to grow.
- Scientists studied how these senescent cells work and found they send out signals that help other cells multiply instead of aging.
- This research helps us understand how axolotls regenerate complex body parts and how these tiny "helper" cells contribute to that amazing ability.
Salamanders are able to regenerate their entire limbs throughout lifespan, through a process that involves significant modulation of cellular plasticity. Limb regeneration is accompanied by the endogenous induction of cellular senescence, a state of irreversible cell cycle arrest associated with profound non-cell-autonomous consequences. While traditionally associated with detrimental physiological effects, here, we show that senescent cells can enhance newt limb regeneration.
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