Exploring nasopharyngeal carcinoma genetics: Bioinformatics insights into pathways and gene associations.

Introduction: The pathogenesis of nasopharyngeal carcinoma (NPC) is intricate, influenced by a combination of factors including host genetics, viral infection and environmental elements, resulting in genetic and epigenetic modifications. Despite a positive prognosis for early-stage patients, most NPC cases are diagnosed at an advanced stage, highlighting the pressing need for enhanced accessibility to early diagnosis and treatment. The underlying molecular pathways driving NPC progression remain elusive.

Karyotype patterns, clinical features, and parental ages of three predominant live born autosomal trisomies of Northeast Malaysia.

Chromosomal abnormality is one of the causes of congenital disorders among newborns. Despite aneuploidy being the major cause of first trimester miscarriages, very few aneuploidies such as trisomies of chromosomes 13, 18 and 21 survive to birth. The results of 4,064 patients referred for cytogenetic analysis at Human Genome Centre, Universiti Sains Malaysia, Kelantan, Malaysia between 2008 and 2019 were reviewed.

Thalassemia in Malaysia.

Malaysia is a multi-ethnic nation, comprising of Malays and other indigenous groups (67.4%), Chinese (24.6%), Indians (7.

An assessment on Islamic banking ethics through some salient points in the prophetic tradition.

Indonesia is experiencing a stable and rapid Islamic economy process since the emergence of Islamic banking. Asides from the development, some scholars argued that Islamic banking does not completely comply with primary Islamic obligations, such as ethics. The use of sharia banking is preferred in Indonesia, even though it only upholds one foundation in Islamic teaching.

Mutation detection in GJB2 gene among Malays with non-syndromic hearing loss.

Objectives: To identify the mutations in the GJB2 gene and to determine its association with non-syndromic hearing loss in Malays.

Methods: A comparative cross sectional study was conducted on a group of children from the deaf schools and the normal schools. A total of 91 buccal cell samples of non-syndromic hearing loss and 91 normal hearing children were taken.

Genetics of cleft lip and palate : a review.

Orofacial clefts, particularly non-syndromic cleft lip with or without cleft palate (CL/P) are the most common craniofacial deformities, affecting one in every 700 to 1000 newborns worldwide. Numerous efforts have been made to understand the etiology of CL/P so as to predict its occurrence and to prevent it from occurring in the future. In the recent years, advances in genetics and molecular biology have begun to reveal the basis of craniofacial development.

The Use of SNPs in Pharmacogenomics Studies.

Pharmacogenomics is the study of how genetic makeup determines the response to a therapeutic intervention. It has the potential to revolutionize the practice of medicine by individualisation of treatment through the use of novel diagnostic tools. This new science should reduce the trial-and-error approach to the choice of treatment and thereby limit the exposure of patients to drugs that are not effective or are toxic for them.

Genetic polymorphism of CYP2D6 in Chinese subjects in Malaysia.

Background: Although Malaysian Chinese share an origin with the mainland Chinese, their evolution has been influenced by intermarriages. With a gene such as CYP2D6, which is highly polymorphic, it is expected that the Malaysian Chinese would exhibit a polymorphism profile different from those of the Chinese populations in other geographical locations.

Objective: To study the genotype distribution of CYP2D6 among the Chinese people in Malaysia.