Publications by authors named "Alvina Gul"

L-type lectin receptor kinases (LECRK) plays a significant role in biotic and abiotic stress response against environmental stimuli in plants. In the Arabidopsis model plant, a total of 45 LECRK was identified but function elucidation is still unresolved. This study carried out a comprehensive analysis of the SNPs associated with L-type lectin protein and how these mutations affect the structure and function of the protein.

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  • Cancer is a major cause of sickness and death worldwide, but treatment methods are improving.
  • CRISPR-Cas is a powerful gene editing tool that helps researchers understand cancer better and find new ways to treat it.
  • This technology can change how cancer is treated by targeting specific genes, making traditional treatments more effective, and personalizing therapies for patients.
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  • The CRISPR-Cas9 method is a groundbreaking tool for editing genes and has changed how scientists can modify DNA.
  • Researchers are exploring how changes in DNA and RNA can affect human diseases, especially through something called epigenetics.
  • New improvements in CRISPR technology are helping scientists better understand and treat diseases by making precise changes to DNA and controlling gene behavior.
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  • Repurposing pharmaceuticals means finding new uses for already approved medications, like changing how they are taken or how much is given.
  • Scientists test these drugs on diseases to see if they work, using past safety information to save time and money.
  • This method is especially useful for fighting bacterial infections, especially as some bacteria become resistant to common antibiotics.
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This review has explored the importance of using a synergistic approach of nano-elicitation and hydroponics to improve plant growth and metabolite production. Furthermore, it emphasizes the significance of green nanotechnology and eco-friendly practices while utilizing this approach to promote the development of a sustainable agriculture system. Nano-elicitation stimulates metabolic processes in plants using nanoparticles (NPs) as elicitors.

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Penicillium expansum is an important phytopathogenic fungus that causes blue mold disease. In this study, the novel mitochondrial genome of P. expansum was sequenced, assembled, annotated, and compared with the previously published Penicillium mitogenomes.

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  • Durum wheat, crucial in the Mediterranean, was analyzed for genetic diversity using SNP markers across 126 landraces from various European and Asian countries, revealing a total of 23,334 polymorphic SNPs.
  • The study identified genetic variations with the highest diversity linked to chromosome 6B, leading to the classification of the landraces into two main subpopulations, although geographical origin did not strongly correlate with genetic relationships.
  • The findings suggest that these durum wheat genotypes and SNP markers are valuable for further research, particularly for mapping traits and conducting genome-wide association studies.
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Environmental nanoremediation is an emerging technology that aims to rapidly and efficiently remove contaminants from the polluted sites using engineered nanomaterials (ENMs). Inorganic nanoparticles which are generally metallic, silica-based, carbon-based, or polymeric in nature serve to remediate through chemical reactions, filtration, or adsorption. Their greater surface area per unit mass and high reactivity enable them to treat groundwater, wastewater, oilfields, and toxic industrial contaminants.

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Environmental variation is the most crucial problem as it is causing food insecurity and negatively impacts food availability, utilization, assessment, and stability. Wheat is the largest and extensively cultivated staple food crop for fulfilling global food requirements. Abiotic stresses including salinity, heavy metal toxicity, drought, extreme temperatures, and oxidative stresses being the primary cause of productivity loss are a serious threat to agronomy.

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Plants require copper for normal growth and development and have evolved an efficient system for copper management based on transport proteins such as P-ATPases, also known as heavy metal ATPases (HMAs). Here, we report HMAs in eleven different Poaceae species, including wheat. Furthermore, the possible role of wheat HMAs in copper stress was investigated.

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Cadmium (Cd) contamination of soils is an environmental concern, as cadmium harms food crops and can therefore impact human health. The use of combinations of biochar (seeded with ) and (as an intercrop) has the potential to reduce the mobilization of Cd from soil mustard plants (). Mustard plants are grown as a food and oil production crop that is consumed worldwide.

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Tomato is a drought-sensitive crop which has high susceptibility to adverse climatic changes. Dehydration-responsive element-binding (DREB) are significant plant transcription factors that have a vital role in regulating plant abiotic stress tolerance by networking with DRE/CRT -regulatory elements in response to stresses. In this study, bioinformatics analysis was performed to conduct the genome-wide identification and characterization of DREB genes and promoter elements in .

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Alternate formulation strategies need to be devised for improving the absorption and bioavailability of drug molecules administered through the intravaginal route. Enhancing the coating of vaginal mucosa can aid the achievement of this goal. The aim of the current study is to develop a mucoadhesive formulation having adequate adhesiveness, spreading, and viscosity profiles that can ensure good tissue absorption of adapalene upon intravaginal application.

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  • Nitrogen is crucial for plant growth and enhancing its biological fixation in leguminous crops like Arachis hypogaea (peanut) is essential for sustainable agriculture.
  • This study successfully identified 42 nod inducing genes in Arachis hypogaea for the first time, utilizing various analyses such as phylogenetic clustering and promoter region assessment.
  • The findings provide insights into the evolutionary relationships of these genes and their potential roles in biological nitrogen fixation, paving the way for future research in agricultural practices.
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  • * A collaborative effort resulted in a fully annotated reference wheat genome published in 2018, followed by the release of genomes from 15 global wheat accessions in 2020, marking the start of the pan-genomic era for wheat.
  • * These developments allow for more efficient genetic analysis using advanced genotyping methods, enhancing marker-assisted selection and genomic selection, which in turn improves key traits like grain yield and stress resistance in wheat breeding.
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is an important enzyme of the phenylpropanoid pathway, regulating the production of several biologically active stilbenoids. These compounds have antioxidant, anti-inflammatory, and anti-cancer properties. However, the detailed characterization of genes in has not yet been performed.

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This study seeks to investigate the interaction profile of the L5 protein of oncolytic adenovirus with the overexpressed surface receptors of pancreatic cancer. This is an important area of research because pancreatic cancer is one of the most fatal malignancies with a very low patient survival rate. Multiple therapies to date to improve the survival rate are reported; however, they show a comparatively low success rate.

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Stress-associated proteins (SAPs) are zinc finger proteins involved in the regulation of various stresses in a variety of plant species. A total of nine genes were identified in . Phylogenetic and synteny analyses were performed to analyze the homology and evolutionary relationship of genes.

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Dehydration Responsive Element Binding (DREB) regulates the expression of numerous stress-responsive genes, and hence plays a pivotal role in abiotic stress responses and tolerance in plants. The study aimed to develop a complete overview of the cis-acting regulatory elements (CAREs) present in S. tuberosum DREB gene promoters.

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Transcription factors are regulatory proteins known to modulate gene expression. These are the critical component of signaling pathways and help in mitigating various developmental and stress responses. Among them, bZIP, BBR, and BZR transcription factor families are well known to play a crucial role in regulating growth, development, and defense responses.

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This study aimed to assess the impact of individual as well as combined application of and in phytoremediation potential of grown in soil contaminated by industrial effluents. In response to five metals; copper, chromium, nickel, lead, and cadmium, results revealed that germination percentage, fresh and dry weights, and photosynthetic pigments of decreased under contaminated soil. On the other hand, electrolyte leakage due to cellular injury, metabolites (proline and glycine betaine), antioxidant enzymes (superoxide dismutase, catalase, peroxidase, ascorbate peroxidase), accumulation of hydrogen peroxide and metals in plant's roots, shoots and leaves increased.

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  • - This study focuses on understanding the genetic factors that allow local wheat landraces from Iran and Pakistan to adapt to their environments by examining a collection of 512 samples using advanced genotyping techniques.
  • - It finds that Pakistani wheat landraces have slightly more genetic diversity than Iranian ones, and they display distinct genetic populations, indicating different evolutionary paths and adaptability strategies.
  • - Significant genetic loci associated with local adaptability were identified, particularly on specific chromosomes related to traits like flowering time and grain size, which could inform future wheat breeding practices.
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  • The study focuses on the StDREB gene family in potatoes, which enhances plant tolerance to abiotic stresses, using bioinformatics to analyze a total of 66 genes.
  • Phylogenetic analysis categorized these genes into six subgroups (A1-A6) and identified their uneven distribution across 12 chromosomes, along with evidence of gene duplication events.
  • The research concludes that understanding StDREB genes' molecular mechanisms will aid in improving potatoes' resistance to environmental stresses.
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Drought is one of the hostile environmental stresses that limit the yield production of crop plants by modulating their growth and development. Peanut () has a wide range of adaptations to arid and semi-arid climates, but its yield is prone to loss due to drought. Other than beneficial fatty acids and micronutrients, peanut harbors various bioactive compounds including flavonoids that hold a prominent position as antioxidants in plants and protect them from oxidative stress.

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