Implementation and Evaluation of a 10-Week Kettlebell Training Load Distribution on Strength and Aerobic Capacity in Recreationally Trained Women.

Objective: : The purpose of this study was to characterize the dynamic distribution of training loads in a kettlebell program and evaluate its effects on muscle strength and aerobic capacity.

Methods: Fourteen recreationally active women with no kettlebell training experience (age: 25.86 ± 5.

Co-Creation in the Development of Digital Therapeutics: A Narrative Review.

Digital therapeutics (DTx) are transforming healthcare delivery through personalised, evidence-based interventions that offer a cost-effective approach to health management. However, their widespread adoption faces significant barriers including privacy concerns, usability issues, and integration challenges within healthcare systems. This review assesses the current evidence on DTx, with a particular focus on the role of co-creation in enhancing design and usability.

Nutritional Value of for Weaner Piglets.

This study evaluates the nutritional value of spray-dried biomass to infer its applicability for weaner piglet feeding. Twenty-four piglets were randomly allocated to four dietary treatments ( = 6) with increasing inclusion (0, 5, 10, and 15%) levels. After a 4-day adaptation period, the digestibility experiment lasted two weeks, with daily excreta collection.

Efficient Biochemical Method for Characterizing and Classifying Related Amyloidogenic Peptides.

Amyloidosis is a group of proteinopathies characterized by the systemic or organ-specific deposition of proteins in the form of amyloid fibers. Nearly 40 proteins play a role in these pathologies, and the structures of the associated fibers are beginning to be determined by Cryo-EM. However, the molecular events underlying the process, such as fiber nucleation and elongation, are poorly understood, which impairs developing efficient therapies.

Expression of a periplasmic β-glucosidase from Yarrowia lipolytica allows efficient cellobiose-xylose co-fermentation by industrial xylose-fermenting Saccharomyces cerevisiae strains.

This study aimed to compare the effects of cellobiose hydrolysis, whether occurring inside or outside the cell, on the ability of Saccharomyces cerevisiae strains to ferment this sugar and then apply the most effective strategy to industrial S. cerevisiae strains. Firstly, two recombinant laboratory S.

Multifunctional Supramolecular Gels with Strong Mechanical Properties Formed by Self-Assembly of Polyoxometalate-Based Coordination Polymers.

Metallogels built in a bottom-up approach by metal coordination and supramolecular interactions have important potential for the elaboration of smart materials. In this context, we present here the formation of supramolecular coordination polymers driven by the complexation of cobalt(II) or zinc(II) ions with polyoxometalate-based hybrids displaying two terpyridine ligands in a linear arrangement. Thanks to the electrostatic interactions between the polyoxometalate cores and metal nodes, the polymer chains self-assemble into fibers that physically cross-link to form gels above a critical concentration.

The effect of genotype and sex on carcass characteristics and fatty acid profile of Pekin broiler ducks.

The aim of this study was to compare two different strains of Pekin duck and to answer one scientific hypothesis: 1) Strain and sex influence live body weight, hot and cold carcass weights and carcass portions weights and yields, fatty acid content, fatty acid total cholesterol and α-tocopherol contents of meat. The study used 50 individuals of each strain in comparison (Cherry Valley and Grimaud) equally divided between both sexes), raised in equal rearing and feeding conditions. The results show that, when raised in equal rearing and feeding conditions and slaughtered at matching age, the strain had no significant influence on live body weight at slaughter, warm and cold carcass weights.

Use of almond hulls in lamb diets - Effects on growth performance and carcass and meat quality.

The effect of partial replacement of cereals by increasing levels of almond hulls (AH) was tested in twenty-four lambs distributed into three dietary treatments: 1) diet without replacement of cereals with AH (0AH); 2) diet with replacement of cereals with 9% of AH (9AH); and 3) diet with replacement of cereals with 18% of AH (18AH). All diets included 40% dehydrated lucerne and 5% soybean oil. Dry matter intake, growth performance, feed costs, carcass traits, meat quality, and lipid oxidative stability of raw and cooked meat during refrigerated storage were evaluated.

Single polyoxometalate-based nanoclusters characterized by infrared absorption nanospectroscopy.

Bottom-up engineering is a very attractive field. However, the periodic organization of molecules on a solid substrate is challenging, particularly in the selection of the appropriate characterization technique which is suitable for both large area and accurate analysis at the nanoscale. Here, this study demonstrates the unambiguous identification of complex molecular layers by infrared absorption microscopy at the nanometric scale.

Aspects of brucellosis vaccination in Maranhão state.

Bovine brucellosis is a zoonosis of great economic and public health relevance. Understanding the epidemiological aspects of this disease is a determining factor to help developing effective strategies and supporting decision-making processes. The aim of the present study is to carry out a situational vaccination diagnosis against brucellosis in Maranhão State's cattle in order to identify challenges set for vaccination operations and to help the Official Veterinary Service to plan health interventions.

Rosa dos Ventos Multicenter Cohort Study of Patients with Reduced or Mildly Reduced Ejection Fraction Heart Failure in Brazil: Rationale and Design.

Background: Brazil is a country with different biomes and social disparities. There are limited data available on regional differences and prognosis of heart failure (HF) in the country.

Objective: The Rosa dos Ventos study aims to investigate regional differences and the current prognosis of HF outpatients with reduced or mildly reduced ejection fraction in Brazil.

Protecting mothers against posttraumatic stress symptoms related to childbirth: What's the role of formal and informal support?

Background And Objectives: The risk and protective factors of posttraumatic stress symptoms related to childbirth (CB-PTSD) have been recently investigated. Although the general support received by the mothers is considered to play a positive role, the precise function of each type of support is still misunderstood. This study aimed to ascertain whether forms of informal and formal support better predict CB-PTSD symptoms and whether adverse delivery experiences and prior psychological issues moderated this relationship.

Optimizing multi-surface modelling of available cadmium as measured in soil pore water and salt extracts of soils amended with compost and lime: The role of organic matter and reactive metal.

The effectiveness of strategies to reduce cadmium (Cd) availability for crop uptake can be assessed using various measures of Cd availability, such as Cd concentration in pore water and Cd extracted with salt solutions. This study evaluated the performance of multi-surface modelling (MSM) to predict dissolved Cd in two Irish tillage soils treated with lime, zinc (Zn) and spent mushroom compost (SMC). Predictions were assessed against Cd measured in three solution media, i.

What are microsatellites and how to choose the best tool: a user-friendly review of SSR and 74 SSR mining tools.

Microsatellites, also known as SSR or STR, are essential molecular markers in genomic research, playing crucial roles in genetic mapping, population genetics, and evolutionary studies. Their applications range from plant breeding to forensics, highlighting their diverse utility across disciplines. Despite their widespread use, traditional methods for SSR analysis are often laborious and time-consuming, requiring significant resources and expertise.

Cardiac autonomic responses to high-intensity kettlebell training in untrained young women: A pilot study.

Background: and purpose: The autonomic recovery after exercise provides information about the cardiovascular overload employed during the training session. The autonomic response over a training course is unclear in exercises performed at high intensities, such as kettlebell training. The study aimed to characterize the cardiac autonomic modulation after exercise in three distinct phases of a high-intensity kettlebell training program in young women.

FLT3 signaling inhibition abrogates opioid tolerance and hyperalgesia while preserving analgesia.

Navigating the duality of opioids' potent analgesia and side effects, including tolerance and hyperalgesia, is a significant challenge in chronic pain management, often prompting hazardous dose escalation to maintain analgesic effects. The peripheral mu-opioid receptor (MOR) is known to mediate these contradictory effects. Here, we show that the fms-like tyrosine kinase receptor 3 (FLT3) in peripheral somatosensory neurons drives morphine tolerance and hyperalgesia in a male rodent model.

Larvicidal activity and chemical composition of four essential oils against Aedes aegypti (Diptera: Culicidae).

The use of botanical insecticides has increased in recent years due to the demand for effective products, particularly against insects resistant to conventional insecticides. Among these is Aedes aegypti, a well-adapted mosquito to urban environments that opportunistically feeds on humans and animals, contributing to the spread of virus. We evaluated the potential of essential oils (EOs) extracted from Eucalyptus citriodora, Eucalyptus staigeriana, Eucalyptus caryophyllus, and Mentha arvensis in terms of their larvicidal activity against Ae.

Malformations of Cortical Development: Updated Imaging Review.

Malformations of cortical development (MCD) are structural anomalies that disrupt the normal process of cortical development. Patients with these anomalies frequently present with seizures, developmental delay, neurologic deficits, and cognitive impairment, resulting in a wide spectrum of neurologic outcomes. The severity and type of malformation, in addition to the genetic pathways of brain development involved, contribute to the observed variability.

Effect of DMSO Addition on the Hexagonal Phase of the System Triton X/Water.

This research studied the role of DMSO in a binary system of Triton X and water in the hexagonal mesophase. One effect of DMSO addition, determined using polarized optical microscopy and small-angle X-ray scattering measurements, is to promote a decrease in the hexagonal to isotropic phase transition temperature, , decreasing the range of temperatures of the hexagonal phase until the hexagonal phase completely disappears when DMSO is added up to 5.0 mol %.

Genome-Wide Association for Morphological and Agronomic Traits in L. Accessions.

Exploring genetic resources through genomic analyses has emerged as a powerful strategy to develop common bean ( L.) cultivars that are both productive and well-adapted to various environments. This study aimed to identify genomic regions linked to morpho-agronomic traits in Mesoamerican and Andean common bean accessions and to elucidate the proteins potentially involved in these traits.