Interaction between escitalopram and ibuprofen or paracetamol: DFT and molecular docking on the drug-drug interactions.

A large number of drugs are introduced each year to treat different diseases. Most of the time, patients suffer from more than one health problem which makes it necessary to take multiple drugs. When drugs are combined, the problem of drug-drug interaction becomes relevant.

Evaluation of serum indirect haemagglutination test results of suspected cystic echinococcosis cases from 2009-2017.

Objective: This study aims to evaluate the serological, radiological and epidemiological analysis of suspected cystic echinococcosis patients, and to assess the positivity rate in the region.

Methods: The retrospective study was conducted at Bursa Uludag University Hospital, Turkey and comprised data from January 2009 to December 2017 related to patients of either gender with suspected cystic echinococcosis who underwent indirect haemagglutination testing. Demographic and clinical data of patients who tested positive were analysed.

Theoretical insights of the drug-drug interaction between favipiravir and ibuprofen: a DFT, QTAIM and drug-likeness investigation.

One of the approaches adopted, as the first treatment method, in previous pandemic viruses before the production of new vaccines or drugs, is to evaluate the effectiveness of existing drugs. Sometimes, it is known that the combination of drugs provides better treatment by increasing the activity of the drugs due to mutual interactions. In this work, we used quantum theory of atoms in molecules and density functional theory to examine the structure and activity relationship between Favipiravir (FPV), a potential antiviral drug for ribonucleic acid viruses, and an inhibitor of influenza virus, and Ibuprofen (IBP), a nonsteroidal anti-inflammatory drug.

Serological Prevalence of in Faculty of Medicine of Bursa Uludağ University During 2016-2018.

Objective: This study aimed to retrospectively investigate IgG and IgM distribution and IgG avidity in serum samples with suspected toxoplasmosis in the medical microbiology serology laboratory of Faculty of Medicine Hospital at Bursa Uludağ University over a 24-month period (January 2016 to December 2018).

Methods: An enzyme-linked fluorescent assay using the VIDAS automated analyzer (BioMérieux, France) was used to determine IgM antibodies, IgG antibodies, and IgG avidity.

Results: The IgM antibody positivity was found to be 1.

Interaction between favipiravir and hydroxychloroquine and their combined drug assessment: in silico investigations.

Unlabelled: Hydroxychloroquine (HCQ) and favipiravir (FPV) are known to be effective antivirals, and there are reports about their use to fight the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) despite that these are not conclusive. The use of combined drugs is common in drug discovery, and thus, we investigated HCQ and FPV as a combined drug. The density functional theory method was used for the optimization of geometries, spectroscopic analysis and calculation of reactivity parameters.

Can the Antivirals Remdesivir and Favipiravir Work Better Jointly? In Silico Insights.

The proverb "Old is gold" is applicable in drug discovery and the proverb "All that Glitters is not Gold" is also appropriate. In the COVID-19 era, there has been a race for drugs to be effective against SARS-CoV-2. There are reports about the uses of Remdesivir and Favipiravir as existing antivirals against virus but none have been conclusive so far.

Laboratory Results of Cystic Echinococcosis in 2017 and 2018.

Objective: This study aimed to retrospectively examine the indirect haemagglutination (IHA) test results of patients suspected of cystic echinococcosis (CE) and admitted to Bursa Uludağ University Health Practice and Research Center Hospital.

Methods: Serum samples in the serology laboratory of our hospital were evaluated using the commercial Cellognost echinococcosis IHA (Siemens Healthcare Diagnostics, Marburg, Germany) test based on the manufacturer's recommendations. In the IHA test, ≥1:64 serum titres were accepted as positive.

Keratitis and Conjunctivitis: A Case Report.

species are vision-threatening agents by causing cornea infections known as keratitis. A 5 year-old kid with the complaints of erythema, eyelid edema, inflammation, limitation of eye movements in the right eye, and having no history of wearing contact lenses or trauma, was diagnosed of conjunctivitis through laboratory examinations in the Ophthalmology clinic. The visual sharpness of the patient improved after the treatment.

Investigation of Seropositivity in Uludağ University Hospital between 2009-2016.

Objective: The aim of this study is to investigate the distribution of anti- immunoglobulin G (IgG) and immünoglobulin M (IgM) antibodies in patients with suspected toxoplasmosis admitted to the Practice and Research Center of Health of the Medical Faculty of Uludağ University.

Methods: The blood samples examined for the presence of anti- IgG antibody and anti- IgM antibody by an enzyme linked fluorescent assay test, anti- IgG avidity value was evaluated by VIDAS (BioMérieux, France) kit.

Results: In our study, anti- IgG seropositivity in 3311 (30.

A Rare Case of Blebharitis: Phthiriasis Palpebrarum.

A six-year-old male patient was admitted to our hospital due to itching and scalding crusts that persisted 10-15 days in both eyes. Upon biomicroscopic examination, 5-6 semi-translucent, yellowish brown living lice attached to the upper eyelashes and a large number of eggs were observed. Following application of pilocarpine hydrochloride (Pilomann 2%, Bausch-Lomb) and topical proparacaine hydrochloride (Alcaine 0.

A Clinical Scoring System for Diagnosis of Ocular Demodicosis.

BACKGROUND Demodex may cause chronic and refractory blepharitis with associated ocular surface problems, and its diagnosis and treatment can be quite challenging. In this study, our aim was to assess the efficacy of tea tree oil in Demodex treatment on caucasian patients in an industrialized region of Turkey, and to develop a systematic scoring system for extremely accurate diagnosis in the absence of advanced facilities. MATERIAL AND METHODS Charts of 412 patients with blepharitis were reviewed.

Cerebral Malaria Treated with Artemisinin in the Intensive Care Unit: A Case Report.

Malaria is a parasitic disease that is starting to be encountered in intensive care units (ICU) worldwide, owing to increasing globalisation. Severe malaria caused by Plasmodium falciparum, is characterised by cerebral malaria, acute renal failure, hypoglycaemia, severe anaemia, splenomegaly and alveolar oedema. We present the case of a 25-yr old male patient who presented to the Emergency Department of Uludag University in Bursa, Turkey in the winter of 2014 with complaints of fever for three days.

[Evaluation of Two Methods (Nativ-Lugol Preparation and Enzyme-Linked Immunosorbent Assay) for Detection of Entamoeba histolytica in Stool Samples].

Objective: This study aims to compare the performance of Native-Lugol examination and EIA Antigen Detection Test using stool samples obtained from patients diagnosed as clinical gastroenteritis and submitted to the Parasitology Laboratory in Uludağ University between January 2010 and February 2011.

Methods: The stool samples taken from 116 patients and sent to the laboratory of parasitology from various clinics including outpatient services have been investigated using Native-Lugol examination and EIA Antigen Detection Kit (Wampole® E. histolytica II Techlab®, Inc.

4-Mercaptophenylboronic acid: conformation, FT-IR, Raman, OH stretching and theoretical studies.

4-Mercaptophenylboronic acid (4-mpba, C6H7BO2S) was investigated experimentally by vibrational spectroscopy. The molecular structure and spectroscopic parameters were studied by computational methods. The molecular dimer was investigated for intermolecular hydrogen bonding.

Investigation of serological results of patients with suspected toxoplasmosis admitted to the ELISA Laboratory of Uludağ University Hospital between 2002-2008.

Objective: The aim of this study is to investigate the distribution of anti-Toxoplasma gondii IgG and IgM antibodies in patients with suspected toxoplasmosis referred to the Uludağ University Medical School, Department of Medical Microbiology Enzyme-Linked Immunosorbent Assay (ELISA) laboratory over a 72-month period (March 2002-December 2008).

Methods: The samples were analyzed using VIDAS (BioMérieux, France) IgG-avidity tests and the fluorescent enzyme-linked assay (ELFA) technique.

Results: Results showed that the prevalence of anti-T.

[The epidemiology of malaria in Bursa--2009-2012].

Objective: Malaria is a common disease in many tropical and subtropical areas, which may threaten life. In this study, we examined the epidemiology of malaria in Bursa province using the data provided by the Province Health Directorate, collected over 2009 to 2012.

Methods: The data include a total of 29.

[The Pneumocystis jirovecii colonization in bronchoalveolar lavage (BAL) and bronchial washing and the comparison of methods which are used in diagnosis].

Introduction: Pneumocystis pneumonia (PCP) which is caused by Pneumocystis jirovecii is usually seen in the patients whose immune system is supressed. It is seriously seen an opportunist infection. In our study; totally 100 bronchoalveolar lavage (BAL) and bronchial washing samples collected by pulmonary disease department.

Coring-out fistulectomy with a newly designed 'fistulectome' for complicated perianal fistulae: a retrospective clinical analysis.

Aim: Conventional surgery for complex anal fistula (AF) is associated with continence disturbance and recurrence. In the hope of reducing these we developed a new mechanical device, the 'fistulectome', to excise the entire fistula tract.

Method: Between March 2001 and April 2011, 136 patients underwent surgery for a complex AF using the fistulectome.

Vibrational spectroscopic investigation of 1-pyrrolidino-1-cyclohexene: a comparative density functional study.

Infrared and Raman spectra of 1-pyrrolidino-1-cyclohexene (1pych) have experimentally been reported in the region of 4000-100 cm(-1). The conformational analysis, optimized geometric parameters, normal mode frequencies and corresponding vibrational assignments of 1pych (C10H17N) have theoretically been examined by means of the Becke-3-Lee-Yang-Parr (B3-LYP) density functional theory (DFT) method together with the 6-31++G(d,p) basis set. Furthermore, reliable vibrational assignments have been made the basis of potential energy distribution (PED) and the thermodynamics functions, highest occupied and lowest unoccupied molecular orbitals (HOMO and LUMO) of 1pych have been predicted.

DFT, FT-IR and Raman investigations of 1-pyrrolidino-1-cyclopentene.

FT-IR and Raman spectra of 1-pyrrolidino-1-cyclopentene (1py1cp) were experimentally reported in the region of 4000-10 cm(-1) and 4000-100 cm(-1), respectively. The optimized geometric parameters, normal mode frequencies and corresponding vibrational assignments of 1py1cp (C9H15N) were theoretically examined by means of the B3LYP hybrid density functional theory (DFT) method together with the 6-31++G(d,p) basis set. Furthermore, reliable vibrational assignments were made on the basis of the potential energy distribution (PED) and the thermodynamics functions, the highest occupied and the lowest unoccupied molecular orbitals (HOMO and LUMO) of 1py1cp were predicted.

Synthesis, growth and vibrational spectroscopic study of a novel coumarinoylthiazole.

An efficient route was developed for the synthesis of novel 3-(2-morpholinyl-4-phenylthiazol-5-oyl)coumarin (MPTC). FT-IR spectrum of MPTC was recorded and analyzed. The crystal structure data are also described.

The investigation of the effect of thermal treatment on bentonites from Turkey with Fourier transform infrared and solid state nuclear magnetic resonance spectroscopic methods.

There is a great deal of interest in the building industry in burned clays for production of building materials. Therefore, the effect of heat treatment on natural bentonite from Turkey was investigated by Fourier transform infrared (FT-IR) between the region of 4000-400cm(-1) and (29)Si, (27)Al magic angle spinning nuclear magnetic resonance (MAS NMR) measurement techniques at various temperatures between 200 and 700°C for 2h. The structural changes were also investigated upon heat treatment.

[The distribution of intestinal parasites detected in the Uludag University Medical Faculty Hospital between 2009-2010].

Objective: Intestinal parasite infection is still an important public health problem. In this study, patients with various gastrointestinal system complaints presenting at various clinics of the Uludag University Medical Faculty, between 2009-2010 were investigated for intestinal parasites.

Methods: All fecal samples were examined with the formol ethyl acetate sedimentation method for helminth ova and protozoan cysts.

FT-IR and Raman spectroscopic and quantum chemical investigations of some metal halide complexes of 1-phenylpiperazine.

New metal halide complexes in the form of M(pp)(2)Cl(2) (where pp=1-phenylpiperazine and M=Pd or Hg) have been prepared for the first time and their FT-IR and FT-Raman spectra are reported in the region of 4000-10 cm(-1) and 4000-50 cm(-1), respectively. The optimized geometric parameters, normal mode frequencies and corresponding vibrational assignments of the present compounds are theoretically examined by means of B3LYP hybrid density functional theory (DFT) method together with Lanl2dz basis set. Furthermore, reliable vibrational assignments made on the basis of potential energy distribution (PED) were calculated and the thermodynamics functions, the highest occupied and the lowest unoccupied molecular orbitals (HOMO and LUMO) of these compounds have been predicted.

[Travel related urinary schistosomiasis: case report].

Schistosomiasis is the second most frequent parasitic infection worldwide after malaria and is a major public health problem in various countries of the world. In our country due to the increasingf travel to endemic regions, the number of cases is also rising. We report herein a case of schistosomiasis who resided in Africa five years earlier and was referred to hospital with hematuria.