Publications by authors named "Alvaro Gomez Tomas"
Background: The survival benefit of sentinel lymph node biopsy (SLNB) in immunocompetent and immunosuppressed patients with high-risk cutaneous squamous cell carcinoma (cSCC) has not been established.
Objective: To determine whether SLNB improves disease-specific survival (DSS) in high-risk cSCC. Secondary objectives were to analyse disease-free survival, nodal recurrence-free survival and overall survival (OS).
Real-world adalimumab survival and discontinuation factors in hidradenitis suppurativa.
J Eur Acad Dermatol Venereol
January 2025
Article Synopsis
- - The study analyzed the survival rate and interruption risks of adalimumab (ADA) treatment in 539 adult patients with hidradenitis suppurativa (HS), providing insights before and after the COVID-19 pandemic.
- - Findings revealed that about 39.92% of patients interrupted ADA, with the main reasons being inefficacy (51.69%) and adverse effects (21.35%); ADA showed a median overall drug survival of 56.2 months.
- - Factors like female gender, prolonged HS diagnosis, and higher HS severity correlated with decreased ADA survival, while post-pandemic trends included younger patients starting treatment at a lower HS stage.
Mucosal melanoma (MM) is an uncommon melanoma subtype affecting mucosal surfaces of the head and neck, anorectal region, and vulvovaginal area. We aimed to present our experience at a tertiary-level hospital regarding MM diagnosis, management, monitoring of progression, mutations, and outcome predictors. We performed a registry-based cohort study including MM cases diagnosed from 2012 to 2022 and retrospectively characterized somatic mutations on , and We employed Kaplan-Meier curves, log-rank tests, and Cox regression analysis to explore prognostic factors and survival outcomes in a cohort of 35 patients, mainly women (63%) with a median age of 70 years.
View Article and Find Full Text PDFImportance: The Skin and UV Neoplasia Transplant Risk Assessment Calculator (SUNTRAC) tool has been developed in the US to facilitate the identification of solid organ transplant recipients (SOTRs) at a higher risk of developing skin cancer. However, it has not yet been validated in populations other than the one used for its creation.
Objective: To provide an external validation of the SUNTRAC tool in different SOTR populations.
Trace elements are a possible risk factor for pancreatic ductal adenocarcinoma (PDAC). However, their role in the occurrence and persistence of KRAS mutations remains unstudied. There appear to be no studies analyzing biomarkers of trace elements and KRAS mutations in any human cancer.
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