Publications by authors named "Alvaro Belgrano"
Life Sci Alliance
April 2022
Article Synopsis
- - Plitidepsin, a cyclic-peptide from marine sources, effectively inhibits SARS-CoV-2 replication by targeting an important host protein, showing its strongest effects in lung tissue compared to blood.
- - A clinical study involving 46 hospitalized COVID-19 patients tested three doses of plitidepsin and primarily focused on safety, while also monitoring viral load changes, mortality, and need for respiratory support.
- - The treatment was generally safe, with some common side effects like nausea, vomiting, and diarrhea; early results indicated significant reductions in viral load over time, though a few patients required additional medical support.
