Ribes nigrum leaf extract downregulates pro-inflammatory gene expression and regulates redox balance in microglial cells.

Background: This study focuses on the investigation of the antioxidant and anti-inflammatory activities of alcohol extracts from Ribes nigrum leaves on murine BV-2 microglial Wt and Acyl-CoA oxidase 1 deficient (Acox1) cell line models, useful for the investigation of some neurodegenerative disorders.

Methods: The extract chemical composition was analyzed via LC-Q-Orbitrap HRMS. Various assays, including DPPH, MTT, and HDCFDA, were used to assess the extract's antioxidant capacity, cell viability, and reactive oxygen species (ROS) production.

The Action Mechanisms, Anti-Cancer and Antibiotic-Modulation Potential of L. Extract.

Background: Herbal medicinal products containing L. (bilberry) fruits and fruit extracts are widely available in the market. Although bilberry leaves and stems are considered as bio-waste, they contain much higher levels of phenolic compounds than fruits.