Publications by authors named "Aluisio Gameiro Filho"
Stem cell-based therapy has gained importance over the past decades due to huge advances in science and technology behind the generation and directed differentiation of pluripotent cells from embryos and adult cells. Preclinical proof-of-concept studies have been followed by clinical trials showing efficacy and safety of transplantation of stem cell-based therapy, which are beginning to establish this as a modality of treatment. Disease candidates of interest are primarily conditions that may benefit from replacing dead or dying cells, including advanced inherited retinal dystrophies and age-related macular degeneration, and predominantly seek to transplant either RPE or photoreceptors, although neurotrophic approaches have also been trialed.
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- Bilateral acute iris transillumination (BAIT) syndrome is a rare and poorly understood eye condition marked by rapid pigment dispersion, iris depigmentation, and pigment accumulation in the eye's anterior chamber.
- A case study describes a 46-year-old healthy woman who experienced BAIT in both eyes after using topical moxifloxacin/dexamethasone for bacterial conjunctivitis.
- The case was further complicated by the development of nonarteritic anterior ischemic optic neuropathy in her left eye following the BAIT syndrome diagnosis.
Article Synopsis
- * The patient underwent various examinations, revealing multiple red patches in her left eye, while her right eye appeared normal.
- * Unilateral cases of this condition are very rare, with only five documented instances in the literature, highlighting its connection to breast cancer.
Conjunctival leiomyosarcoma.
Aluisio Rosa Gameiro Filho Ana Marisa Pires Castello Branco Moacyr Pezati Rigueiro Melina Correia Morales Rubens N Belfort
Am J Ophthalmol Case Rep
June 2022
Article Synopsis
- - Leiomyosarcoma (LMS) is a rare type of soft tissue sarcoma that typically occurs in muscle but can occasionally affect the eye, particularly the conjunctiva and orbit.
- - A case study detailed a 45-year-old man with a recurrent conjunctival mass diagnosed as grade 1 leiomyosarcoma, which was treated by enucleation after the mass became quickly invasive.
- - Due to the tumor's rarity and similarity to other conditions, proper biopsy is crucial for diagnosis, and while there isn't a standard treatment, complete surgical excision is necessary for the best outcomes.
Article Synopsis
- Melkersson-Rosenthal syndrome (MRS) is a rare disorder characterized by facial paralysis, facial swelling, and fissured tongue, with no known causes.
- The case study discusses a 59-year-old woman experiencing asymmetric eyelid swelling, which was diagnosed as the monosymptomatic form of MRS after a skin biopsy.
- Treatment involved multiple triamcinolone injections, but after a year of improvement, the swelling recurred, leading to the use of Tacrolimus ointment, which significantly reduced the eyelid edema.
Article Synopsis
- The case study discusses a 63-year-old patient with a history of choroidal melanoma who experienced progressive vision loss due to acute exudative polymorphous paraneoplastic vitelliform maculopathy (AEPPVM).
- The patient's examination revealed multiple serous retinal detachments, and further tests confirmed AEPPVM alongside identified metastases to the pancreas, liver, and central nervous system.
- The findings suggest that AEPPVM should be considered in patients with retinal detachments, regardless of a melanoma history, but there is no established link between AEPPVM and pancreatic metastasis in existing literature.
Ocular and cutaneous sporotrichosis.
Aluisio Rosa Gameiro Filho Carolina Tagliari Estacia Rodrigo Rosa Gameiro Leandro de Mattos Fonseca Vieira Daniella Socci da Costa
Am J Ophthalmol Case Rep
December 2020
Article Synopsis
- Sporotrichosis is a widespread fungal infection often seen in a lymphocutaneous form, and when it affects the eye, it typically involves conjunctival and surrounding tissues.
- A case study is presented involving a 13-year-old girl with nodules near her left eye that developed over the past month.
- In Brazil, where sporotrichosis is hyperendemic, diagnosis relies on clinical signs, patient history, and lab culture; medical professionals need to recognize this condition.