Publications by authors named "Altyn Rymbek"
Transient exposure to ketamine can trigger lasting changes in behavior and mood. We found that brief ketamine exposure causes long-term suppression of futility-induced passivity in larval zebrafish, reversing the "giving-up" response that normally occurs when swimming fails to cause forward movement. Whole-brain imaging revealed that ketamine hyperactivates the norepinephrine-astroglia circuit responsible for passivity.
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- - Both neurons and glia use neuromodulatory substances to communicate, but how they compute information in these networks is not fully understood.
- - In larval zebrafish, norepinephrine causes quick excitation followed by delayed behavior inhibition, which is partially mediated by astroglial release of ATP that converts to adenosine to suppress behavior.
- - This study, along with another involving mice, highlights the important role of astroglial purinergic signaling in regulating behavior and brain activity transitions driven by norepinephrine, showcasing a conserved mechanism across species.