Early markers of baked milk and egg tolerance in young children with IgE-mediated immediate reactions.

Children with milk and egg allergies have outcomes in which, three-quarters are tolerant to baked forms of the allergenic food. Identifying predictors of tolerance to baked foods for IgE-mediated immediate-type reactions may guide the early introduction of baked allergens to diet and tolerance development. This study explores factors associated with early tolerance to baked foods.

LTβR deficiency causes lymph node aplasia and impaired B cell differentiation.

Secondary lymphoid organs (SLOs) provide the confined microenvironment required for stromal cells to interact with immune cells to initiate adaptive immune responses resulting in B cell differentiation. Here, we studied three patients from two families with functional hyposplenism, absence of tonsils, and complete lymph node aplasia, leading to recurrent bacterial and viral infections. We identified biallelic loss-of-function mutations in encoding the lymphotoxin beta receptor (LTβR), primarily expressed on stromal cells.

The effect of body mass index on complications in cardiac implantable electronic device surgery.

Background: Cardiac implantable electronic device (CIED) procedures are prone to complications. In our study, we investigated the effect of body mass index (BMI) on CIED-related complications.

Methods: 1676 patients who had undergone CIED surgery (de novo implantation, system upgrade, generator change, pocket revision or lead replacement) at two heart centers in Turkey and met the study criteria were included in our study.

Expanding the clinical and immunological phenotypes of PAX1-deficient SCID and CID patients.

Paired box 1 (PAX1) deficiency has been reported in a small number of patients diagnosed with otofaciocervical syndrome type 2 (OFCS2). We described six new patients who demonstrated variable clinical penetrance. Reduced transcriptional activity of pathogenic variants confirmed partial or complete PAX1 deficiency.

Effect of sodium-glucose co-transporter-2 inhibitors on coronary blood flow in patients with type 2 diabetes mellitus.

Objective: Type 2 diabetes mellitus (T2DM) is known to be associated with endothelial dysfunction (ED). Reducing ED can attenuate the occurrence of cardiovascular diseases. One of the indicators of ED is decreased coronary blood flow (CBF).

Level of Awareness of Acquired Hemophilia A Among Physicians in Türkiye: A Survey Study.

This survey study aimed to evaluate the level of awareness and knowledge of acquired hemophilia A (AHA) among physicians from various specialties. Data were collected by administering a questionnaire containing questions about two patient profiles to evaluate the approaches of physicians from different specialties. The study included a total of 945 physicians.

Low-dose docetaxel/cisplatin - leucovorin and 46 hour infusional fluorouracil in metastatic gastric carcinoma.

Background: Phase II and III trials of docetaxel, cisplatin and fluorouracil (DCF) have shown superior efficacy versus cisplatin and fluorouracil alone but with high rates of hematologic toxicity in metastatic gastric cancer cases. To reduce toxicity while maintaining the efficacy of DCF, we investigated low dose docetaxel (D), cispatin (C) - leucovorin and fluorouracil (De Gramont regimen).

Patient And Methods: Chemotherapy-naive patients with metastatic gastric cancer (MGC) received D 60 mg/m2 on day 1 and cisplatin 30 mg/m2 on day 1-2 and the De Gramont regimen (Folinic acid 400 mg/m2 on day 1 and 5-FU 2400 mg/m2/46 h continuous infusion) every 3 weeks.

Visfatin may be a novel marker for identifying stages of essential hypertension in advanced age patients.

Objective: Visfatin is a peptide that is secreted from visceral fat. It has been reported to be associated with inflammation and endothelial dysfunction. However, little is known about its function in hypertension.

Vinorelbine in combination with carboplatin followed by single-agent consolidation therapy for unresectable localized or metastatic non-small-cell lung carcinomas.

Background: Adding more than four cycles of the combination regimen increase toxicities. The availability of an intravenous (i.v.

Feasibility of volume-of-interest (VOI) scanning technique in cone beam breast CT--a preliminary study.

This work is to demonstrate that high quality cone beam CT images can be generated for a volume of interest (VOI) and to investigate the exposure reduction effect, dose saving, and scatter reduction with the VOI scanning technique. The VOI scanning technique involves inserting a filtering mask between the x-ray source and the breast during image acquisition. The mask has an opening to allow full x-ray exposure to be delivered to a preselected VOI and a lower, filtered exposure to the region outside the VOI.

Scatter rejection and low-contrast performance of a slot-scan digital chest radiography system with electronic aft-collimation: a chest phantom study.

Anti-scatter grids have been widely used to reject scatter and increase the perceptibility of low-contrast object in chest radiography; however they also attenuate the primary x-rays, resulting in a substantial degradation of primary information. Compensation for this degradation requires the use of higher exposure technique hence higher dose to the patient. A more efficient approach to reject scatter is the slot-scan imaging technique which employs a narrow scanning x-ray fan beam in conjunction with a slit or slot shaped solid state detector or an area detector used with an aft-collimator.

An Accurate Scatter Measurement and Correction Technique for Cone Beam Breast CT Imaging Using Scanning Sampled Measurement (SSM) Technique.

We developed and investigated a scanning sampled measurement (SSM) technique for scatter measurement and correction in cone beam breast CT imaging. A cylindrical polypropylene phantom (water equivalent) was mounted on a rotating table in a stationary gantry experimental cone beam breast CT imaging system. A 2-D array of lead beads, with the beads set apart about ~1 cm from each other and slightly tilted vertically, was placed between the object and x-ray source.

Spatial resolution properties in cone beam CT: a simulation study.

This work is intended to investigate the spatial resolution properties in cone beam CT by estimating the point spread functions (PSFs) in the reconstructed 3D images through simulation. The point objects were modeled as 3D delta functions. Their projections onto the detector plane were analytically derived and blurred with 2D PSFs estimated and used to represent the detector and focal spot blurring effects.

Comparison of two detector systems for cone beam CT small animal imaging - a preliminary study.

To compare two detector systems - one based on the charge-coupled device (CCD) and image amplifier, the other based on a-Si/CsI flat panel, for cone beam computed-tomography (CT) imaging of small animals.A high resolution, high framing rate detector system for the cone beam CT imaging of small animals was developed. The system consists of a 2048x3072x12 bit CCD optically coupled to an image amplifier and an x-ray phosphor screen.

A post-reconstruction method to correct cupping artifacts in cone beam breast computed tomography.

In cone beam breast computed tomography (CT), scattered radiation leads to nonuniform biasing of CT numbers known as a cupping artifact. Besides being visual distractions, cupping artifacts appear as background nonuniformities, which impair efficient gray scale windowing and pose a problem in threshold based volume visualization/segmentation. To overcome this problem, we have developed a background nonuniformity correction method specifically designed for cone beam breast CT.

Visibility of microcalcification in cone beam breast CT: effects of X-ray tube voltage and radiation dose.

Mammography is the only technique currently used for detecting microcalcification (MC) clusters, an early indicator of breast cancer. However, mammographic images superimpose a three-dimensional compressed breast image onto two-dimensional projection views, resulting in overlapped anatomical breast structures that may obscure the detection and visualization of MCs. One possible solution to this problem is the use of cone beam computed tomography (CBCT) with a flat-panel (FP) digital detector.

Cone Beam Breast CT with a Flat Panel Detector- Simulation, Implementation and Demonstration.

This paper describes our experiences in the simulation, implementation and application of a flat panel detector based cone beam computed tomography (CT) imaging system for dedicated 3-D breast imaging. In our simulation study, the breast was analytically modeled as a cylinder of breast tissue loosely molded into cylindrical shape with embedded soft tissue masses and calcifications. Attenuation coefficients for various types of breast tissue, soft tissue masses and calcifications were estimated for various kVp's to generate simulated image signals.

An alternate line erasure and readout (ALER) method for implementing slot-scan imaging technique with a flat-panel detector--initial experiences.

This paper describes and demonstrates an electronic collimation method, referred to as the alternate line erasure and readout (ALER) technique, for implementing slot-scan digital radiography technique with an amorphous silicon (a-Si) thin-film transistor (TFT) array based flat-panel detector. An amorphus selenium (a-Se) flat-panel detector was modified to implement the ALER technique for slot-scan imaging. A stepping-motor driven fore-collimator was mounted in front of an X-ray tube to generate a scanning X-ray fan beam.

Procarbazine, CCNU, vincristine combination in the treatment of brain tumors.

Forty patients with primary malignant brain tumor were treated by combination chemotherapy after prior treatment with surgery and radiotherapy. The chemotherapy schedule consisted of PCV: procarbazine per os, 100 mg/m2, during 14 consecutive days; CCNU, per os, 80 mg/m2 on day 1 and vincristine, intravenously, 1.4 mg/m2 on days 1 and 14.