Publications by authors named "Altozano J"
Characteristics and outcomes of advanced melanoma patients with complete response and elective discontinuation of first-line anti-programmed death-1 monotherapy: A real-world multicentre observational cohort study.
Pigment Cell Melanoma Res
September 2023
Anti-programmed death-1 (anti-PD1) treatment has significantly improved outcomes of advanced melanoma with a considerable percentage of patients achieving complete response (CR). This real-world study analyzed the feasibility of elective anti-PD1 discontinuation in advanced melanoma patients with CR and evaluated factors related to sustained response. Thirty-five patients with advanced cutaneous or primary unknown melanoma with CR to nivolumab or pembrolizumab from 11 centers were included.
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- Thromboembolic complications are a significant issue in cancer patients, increasing both morbidity and mortality, prompting the Spanish Society of Medical Oncology to establish a registry for better understanding of cancer-associated thrombosis (CAT).
- The TESEO study is an ongoing, multicentric registry that tracks newly diagnosed thromboembolic events in adult cancer patients, focusing on various health conditions and treatment responses to enhance clinical management of CAT.
- The registry collects comprehensive data over time, monitoring outcomes like rethrombosis and survival to provide insights on how the prognosis for cancer patients changes based on the timing and context of thrombus occurrences.
The main objective of the study was to evaluate the efficacy and safety of dabrafenib alone or combined with trametinib for compassionate use in patients with metastatic melanoma.This retrospective, observational study involved 135 patients with unresectable stage IIIC or stage IV melanoma from an expanded-access program at 30 Spanish centers.Forty-eight patients received dabrafenib monotherapy and 87 received combination dabrafenib and trametinib; 4.
View Article and Find Full Text PDFDissemination of neoplastic cells into the cerebrospinal fluid (CSF) and leptomeninges is a devastating complication in patients with epithelial cell neoplasia (leptomeningeal carcinomatosis [LC]) and lymphomas (lymphomatous meningitis [LyM]). Information about the surrounding inflammatory cell populations is scarce. In this study, flow cytometry immunophenotyping was used to describe the distribution of the main leukocyte populations in the CSF of 83 patients diagnosed with neoplastic meningitis (LC, n = 65; LyM, n = 18).
View Article and Find Full Text PDFEight patients with Hodgkin's disease who were seropositive to human immunodeficiency virus (HIV), 6 of them being heroin addicts and one a homosexual, were studied. Histological examination showed 4 cases of lymphocytic depletion, 2 cases of mixed cellularity, 1 nodular sclerosis, and one not classifiable. There were five cases of stage IV-B and 3 IIIs-B.
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