Publications by authors named "Alton O Sartor"
Although prostate cancer is the type of cancer most commonly survived by men in the United States, it remains the second most common cause of death from cancer, largely owing to metastatic disease. Patients with metastatic castration-resistant prostate cancer (mCRPC) whose disease has progressed on standard-of-care therapies have few options and a poor prognosis. Prostate-specific membrane antigen (PSMA) is a type II integral membrane protein that is commonly expressed in prostate cancer.
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- Retrotransposons, especially the L1 element, significantly influence mammalian genomes and human diseases, comprising 17% of the human genome despite most having defects.
- The study tested RNA-Seq data from prostate cancer cells to compare the quality and effort required for identifying expressed L1, finding minimal data loss with whole-cell, strand-specific RNA-Seq compared to cytoplasmic RNA-Seq, though it required more manual curation.
- The research concludes that with careful manual curation, both cytoplasmic and whole-cell stranded RNA-Seq datasets can effectively identify expressed L1 loci, even though non-strand-specific datasets result in significant data loss.
The mixed-lineage leukemia (MLL) protein acts as a histone methyltransferase regulating multiple genetic elements. Rearrangements of the MLL gene result in expression of MLL-fusion proteins that occur in some acute leukemias and are associated with poor prognosis. The MLL protein complex has been shown to interact with the androgen receptor via the MLL-menin subunit, thus promoting gene activation.
View Article and Find Full Text PDFIntroduction: Androgen deprivation therapy (ADT) is commonly utilized in the management of both localized and advanced adenocarcinoma of the prostate. The use of ADT is associated with several adverse events, physical changes, and development of medical comorbidities/mortality.
Aim: The current article reviews known adverse events associated with ADT as well as treatment options, where available.