Selection and Receipt of Kidney Replacement in Critically Ill Older Patients with AKI.

Background And Objectives: Older patients in the intensive care unit are at greater risk of AKI; however, use of kidney replacement therapy in this population is poorly characterized. We describe the triggers and outcomes associated with kidney replacement therapy in older patients with AKI in the intensive care unit.

Design, Setting, Participants, & Measurements: Our study was a prospective cohort study in 16 Canadian hospitals from September 2013 to November 2015.

Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study.

Background: Functional capacity is an important component of risk assessment for major surgery. Doctors' clinical subjective assessment of patients' functional capacity has uncertain accuracy. We did a study to compare preoperative subjective assessment with alternative markers of fitness (cardiopulmonary exercise testing [CPET], scores on the Duke Activity Status Index [DASI] questionnaire, and serum N-terminal pro-B-type natriuretic peptide [NT pro-BNP] concentrations) for predicting death or complications after major elective non-cardiac surgery.

Reorienting in virtual 3D environments: do adult humans use principal axes, medial axes or local geometry?

Studies have shown that animals, including humans, use the geometric properties of environments to orient. It has been proposed that orientation is accomplished primarily by encoding the principal axes (i.e.