Publications by authors named "Altay Savalan"
Background/aim: The application of biocompatible heavy metal-free and cationic AgS NIR quantum dots (QDs), which have intense luminosity in the 700-900 nm medical range, as a nonviral gene delivery system paves the way to overcome autofluorescence and easily track the delivery of genes in real time.
Materials And Methods: The newly developed small and colloidally stable 2-mercaptopropionic acid (MPA)-capped AgS aqueous quantum dots electrostatically complexed with linear polyethyleneimine (AgS@2MPA/LPEI) were investigated for the first time both as a strong fluorescent probe and as a vector for nonviral gene delivery for the highest tracking of the system and delivery of genes into the nuclei of different cancer cells. The synthesized AgS@2MPA/LPEI quantum dots demonstrated strong optical imaging properties and were used to deliver a green fluorescent protein (GFP) plasmid as a standard gene.