The interplay of senescence and MMPs in myocardial infarction: implications for cardiac aging and therapeutics.

Aging is associated with a marked increase in cardiovascular diseases, such as myocardial infarction (MI). Cellular senescence is also a crucial factor in the development of age-related MI. Matrix metalloproteinases (MMPs) interaction with cellular senescence is a critical determinant of MI development and outcomes, most notably in the aged heart.

Targeting senescence and GATA4 in age-related cardiovascular disease: a comprehensive approach.

The growing prevalence of age-related cardiovascular diseases (CVDs) poses significant health challenges, necessitating the formulation of novel treatment approaches. GATA4, a vital transcription factor identified for modulating cardiovascular biology and cellular senescence, is recognized for its critical involvement in CVD pathogenesis. This review collected relevant studies from PubMed, Google Scholar, and Science Direct using search terms like 'GATA4,' 'cellular senescence,' 'coronary artery diseases,' 'hypertension,' 'heart failure,' 'arrhythmias,' 'congenital heart diseases,' 'cardiomyopathy,' and 'cardiovascular disease.

The Risk of Leakage and Bleeding After Using the Ezisurg Endostapler Technique for Bariatric Surgery.

Background: Obesity is a growing global health issue, with a prevalence rate of 28.8% in Jordan. Bariatric surgery is the most effective treatment for morbid obesity, yet complications such as postoperative bleeding and leakage remain significant concerns.

Cloud computing practice activities and mental capacity on developing reproductive health and cognitive absorption.

The current study aims to determine how the interactions between practice (distributed/focused) and mental capacity (high/low) in the cloud-computing environment (CCE) affect the development of reproductive health skills and cognitive absorption. The study employed an experimental design, and it included a categorical variable for mental capacity (low/high) and an independent variable with two types of activities (distributed/focused). The research sample consisted of 240 students from the College of Science and College of Applied Medical Sciences at the University of Hail's.

Hyperlipidemia in Saudi Arabian Patients With Systemic Lupus Erythematosus.

Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease associated with increased cardiovascular risk, partly due to dyslipidemia. This study aimed to evaluate the lipid profiles of Saudi Arabian patients with SLE and examine the impact of hydroxychloroquine (HCQ) and steroid use on these profiles, with a particular focus on patients with lupus nephritis. Methods A retrospective observational study was conducted at King Saud Medical City, Riyadh, Saudi Arabia, including SLE patients treated at the hospital's rheumatology clinic between July 2023 and December 2023.

Chronic kidney disease and aging: dissecting the p53/p21 pathway as a therapeutic target.

Chronic kidney diseases (CKD) are a group of multi-factorial disorders that markedly impair kidney functions with progressive renal deterioration. Aging contributes to age-specific phenotypes in kidneys, which undergo several structural and functional alterations, such as a decline in regenerative capacity and increased fibrosis, inflammation, and tubular atrophy, all predisposing them to disease and increasing their susceptibility to injury while impeding their recovery. A central feature of these age-related processes is the activation of the p53/p21 pathway signaling.

Novel approach for predicting fake news stance detection using large word embedding blending and customized CNN model.

The proliferation of fake news is one of the major problems that causes personal and societal harm. In today's fast-paced digital age, misinformation spreads rapidly, often leaving individuals without the time to verify the authenticity of the information. This can cause irreparable damage to personal reputations and organizational credibility.

Shifting Trends of Antimicrobial Resistance Patterns Among Uropathogenic Bacteria Before and During the COVID-19 Pandemic.

Urinary tract infections (UTIs) represent a significant global health concern, primarily caused by uropathogenic bacteria and their rising trend of antimicrobial resistance (AMR). This study investigates the prevalence and pattern of AMR among uropathogenic bacteria during the COVID-19 pandemic, highlighting its impact on antimicrobial usage and resistance trends. This retrospective cross-sectional study, conducted at King Fahad Medical City, Riyadh, Saudi Arabia, from January 1, 2018, to December 31, 2022, analyzed 10,031 patients with positive urine cultures for resistance patterns pre-COVID-19 and during COVID-19.

Preparation and characterizations of chitosan-octanoate nanoparticles for efficient delivery of curcumin into prostate cancer cells.

The goal of the research was to develop a hydrophobic octanoate salt of chitosan (CS-OA) and use the salt as a nanoparticle platform for the delivery of curcumin (CUR) into prostate cancer cells. The nanoprecipitation technique was used to prepare the nanoparticles, which were measured for particle size and encapsulation efficacy relative to CUR-CS nanoparticles. The cytotoxicity of CUR-OA-CS nanoparticles was evaluated in prostate cancerous cells (PC3 and DU145) in comparison with the corresponding blank nanoparticles and hydroalcoholic CUR solution.

The role of CD95 in modulating CAR T-cell therapy: Challenges and therapeutic opportunities in oncology.

CAR T cell therapy has revolutionized how we deliver cancer treatment, most notably for hematologic cancers, by compelling T cells to recognize and kill tumor cells. Nevertheless, current obstacles to utilizing this therapy in solid tumors and overcoming cancer resistance include radicalization. This review discusses how CD95 modulation can boost CAR T cell efficacy.

Risk factors and characteristics of intraoperative pressure injuries caused by medical devices and adhesives: A case-control retrospective study.

Background: Undesirable injuries during the intraoperative period, such as pressure injuries caused by improper positioning, medical devices, or adhesive tapes, can lead to patient harm and decreased satisfaction. This study aims to identify the risk factors of pressure injuries during the intraoperative period and the characteristics of these injuries.

Methods: A retrospective case-control study was conducted at King Khaled University Hospital in Riyadh, Saudi Arabia.

The incidence and risk factors of post-transplant diabetes mellitus in living donor kidney transplantation patients: a retrospective study.

Background: Post-transplant diabetes mellitus (PTDM) is a well-known complication of kidney transplantation that significantly impacts recipient morbidity and mortality. Over the recent years, the incidence of PTDM has increased considerably worldwide. Therefore, the primary purpose of this study was to evaluate the incidence and risk factors for PTDM in living donor kidney transplantation patients in Riyadh, Saudi Arabia.

Correction: A neural network model for online one-shot storage of pattern sequences.

[This corrects the article DOI: 10.1371/journal.pone.

Therapeutic Potential of lncRNAs in Regulating Disulfidptosis for Cancer Treatment.

Non-coding RNAs (lncRNAs) play critical roles in various cellular processes, including a novel form of regulated cell death known as disulfidptosis, characterized by accumulating protein disulfide bonds and severe endoplasmic reticulum stress. This review highlights the therapeutic potential of lncRNAs in regulating disulfidptosis for cancer treatment, emphasizing their influence on key pathway components such as GPX4, SLC7A11, and PDIA family members. Recent studies have demonstrated that targeting specific lncRNAs can sensitize cancer cells to disulfidptosis, offering a promising approach to cancer therapy.

Targeting the p53-p21 axis in liver cancer: Linking cellular senescence to tumor suppression and progression.

Liver cancer is a major health epidemic worldwide, mainly due to its high mortality rates and limited treatment options. The association of cellular senescence to tumorigenesis and the cancer hallmarks remains a subject of interest in cancer biology. The p53-p21 signalling axis is an important regulator in restoring the cell's balance by supporting tumor suppression and tumorigenesis in liver cancer.

Stealthy data integrity attack identification in smart grid networks utilizing deep denoising autoencoder.

Smart grids arose as the largest cyber-physical systems with the integration of sophisticated control, computing, and state-of-the-art communications. Like all cyber-physical systems, the smart grids are vulnerable to malicious cyber assaults due to their enormous dependency on communication networks. Various machine learning-based schemes are being investigated in the industry and academia to develop robust defense mechanisms to counter cyber assaults.

An automated approach to predict diabetic patients using KNN imputation and effective data mining techniques.

Diabetes is thought to be the most common illness in underdeveloped nations. Early detection and competent medical care are crucial steps in reducing the effects of diabetes. Examining the signs associated with diabetes is one of the most effective ways to identify the condition.

The effects of cross-language overlap and semantic transparency on the processing of L2 collocations.

Although extensive research has been carried out on collocation processing, it is still unclear how cross-language overlap and transparency influence the processing of collocations by L2 learners. In the current study, a phrase judgment task was used to investigate the processing of congruent (i.e.

Trimetazidine Alleviates Bleomycin-Induced Pulmonary Fibrosis by Targeting the Long Noncoding RNA CBR3-AS1-Mediated miRNA-29 and Resistin-Like Molecule alpha 1: Deciphering a Novel Trifecta Role of LncRNA CBR3-AS1/miRNA-29/FIZZ1 Axis in Lung Fibrosis.

Introduction: Pulmonary fibrosis (PF) and tissue remodeling can greatly impair pulmonary function and often lead to fatal outcomes.

Methodology: In the present study, we explored a novel molecular interplay of long noncoding (Lnc) RNA CBR3-AS1/ miRNA-29/ FIZZ1 axis in moderating the inflammatory processes, immunological responses, and oxidative stress pathways in bleomycin (BLM)-induced lung fibrosis. Furthermore, we investigated the pharmacological potential of Trimetazidine (TMZ) in ameliorating lung fibrosis.

Effectiveness of Continuous Glucose Monitoring in Glucose Control and Quality of Life Among Type 1 Diabetic Patients in Madina City: A Cross-Sectional Study.

Introduction: Diabetes is a growing global health problem, affecting millions of people worldwide and in Saudi Arabia in particular. Continuous glucose monitoring (CGM) offers real-time glucose levels, alerts, and 24/7 coverage, making it an affordable treatment option. The study aimed to assess CGM's effect on diabetes control and quality of life among type 1 adult diabetic patients in Saudi Arabia.

Evaluation of Normal Ranges of Wrist Radiologic Indexes in Jordanian Population.

Background: The wrist is a complex joint that plays a role in several everyday tasks. Various radiological indices have been created to assess the alignment and structure of the wrist using standard X-ray images. Nevertheless, these indicators may differ based on variables such as age, gender, ethnicity, handedness, and wrist position.