Test-retest reliability of the Arabic version of the Pittsburgh Sleep Quality Index.

This study aimed to assess the test-retest reliability and validity of the Arabic version of the Pittsburgh Sleep Quality Index (A-PSQI), a 19-item sleep evaluation tool, in a population of medical students and interns in Saudi Arabia. Following a 16-person pilot study, 202 participants completed 2 A-PSQI questionnaires with a 2-week test-retest interval to avoid a carryover effect. Statistical analysis using RStudio included Cronbach alpha, Spearman rank correlation, and the intraclass correlation coefficient (ICC).

Food Safety: Pathological and Biochemical Responses of Nile Tilapia ( to Parasitological Infestation and Heavy Metals Pollution in Aquaculture System, Jeddah, Saudi Arabia.

Objective: The study aims to assess the overall safety of cultured tilapias in Jeddah City, Saudi Arabia by assessing the impact of infection and anthropogenic pollution on farmed tilapias based on fish sex, body weight, length, and heavy metals contamination.

Materials And Methods: A total of 111 fish were collected from an aquaculture farm in Hada Al-Sham, Jeddah, Saudi Arabia. Physicochemical parameters of water from the culture system were evaluated.

The effects of the paramedics' field work on their mental status in Jeddah.

Background: Paramedics are continuously exposed to stressful events, making them liable to mental disorders. This study assesses the health of paramedics in Jeddah, focusing on their mental, emotional, and physical well-being.

Methods: This cross-sectional study included fieldwork paramedics in Jeddah through an online survey distributed on social media.

An AI-Driven Model to Enhance Sustainability for the Detection of Cyber Threats in IoT Environments.

In the face of constantly changing cyber threats, a variety of actions, tools, and regulations must be considered to safeguard information assets and guarantee the confidentiality, reliability, and availability of digital resources. The purpose of this research is to create an artificial intelligence (AI)-driven system to enhance sustainability for cyber threat detection in Internet of Things (IoT) environments. This study proposes a modern technique named Artificial Fish Swarm-driven Weight-normalized Adaboost (AF-WAdaBoost) for optimizing accuracy and sustainability in identifying attacks, thus contributing to heightening security in IoT environments.

Immuno-therapeutic and prophylactic potential of antigens for inflammatory bowel diseases.

Ulcerative colitis (UC), a severe chronic inflammatory disorder of the colon, is one of the inflammatory bowel diseases (IBD) that affects humans and several domestic animal species, including cats and dogs. Helminth infections and autoimmune diseases are inversely correlated, as explained by the hygiene hypothesis, which suggests that IBD is infrequent in countries where helminth infections are common but more prevalent in developed nations. This study investigated the therapeutic and prophylactic potential of () antigens in an experimental colitis model for IBD.

Children with sickle cell disease: are they protected from serious COVID-19?

Background: COVID-19, the pandemic that hit the world in 2020, resulted in millions of deaths, with the elderly and adults succumbing to the disease more often than children. However, the presence of underlying morbidities increased the risk of death. Sickle cell disease (SCD) was previously classified as a major risk factor for severe COVID-19 disease.

Enhancing workflow efficiency with a modified Firefly Algorithm for hybrid cloud edge environments.

Efficient scheduling of scientific workflows in hybrid cloud-edge environments is crucial for optimizing resource utilization and minimizing completion time. In this study, we evaluate various scheduling algorithms, emphasizing the Modified Firefly Optimization Algorithm (ModFOA) and comparing it with established methods such as Ant Colony Optimization (ACO), Genetic Algorithm (GA), and Particle Swarm Optimization (PSO). We investigate key performance metrics, including makespan, resource utilization, and energy consumption, across both cloud and edge configurations.

Zingiber officinale Ameliorates Acute Toxoplasmosis-Induced Pathology in Mice.

Background: Toxoplasma gondii (T. gondii) infects one third of the world's population with significant illness, mainly among immunocompromised individuals and pregnant women. Treatment options for toxoplasmosis are limited which signifies the need for novel, potent, and safe therapeutic options.

Betalains Mitigate Parasitemia and Brain Oxidative Stress Induced by in Mice.

Although many drugs have been discovered to treat malaria infection, many of them face resistance from the host's body with long-term use. Therefore, this study aimed to evaluate the activity of betalains (from ) and chloroquine (a reference drug) against brain oxidative stress induced by in male mice. Two protocols were applied in this study: the therapeutic and prophylactic protocols.

Current genetic models for studying congenital heart diseases: Advantages and disadvantages.

Congenital heart disease (CHD) encompasses a diverse range of structural and functional anomalies that affect the heart and the major blood vessels. Epidemiological studies have documented a global increase in CHD prevalence, which can be attributed to advancements in diagnostic technologies. Extensive research has identified a plethora of CHD-related genes, providing insights into the biochemical pathways and molecular mechanisms underlying this pathological state.

Green Synthesis of Chitosan/Silver Nanoparticles Using Extract and Its Potential Anti-Cryptosporidiosis Effect.

() is one of the most prevalent species infecting humans and animals. Currently, the only FDA-licensed drug to treat cryptosporidiosis is nitazoxanide (NTZ), with no efficacy in immunocompromised hosts. () has demonstrated anti-protozoal activities.

Effect of the COVID-19 Pandemic on the Performance of Undergraduate Healthcare Students During Their Internship in Saudi Arabia.

Introduction: The coronavirus disease (COVID-19) is an infectious disease that has rapidly spread on a global scale. The entire world has fought tirelessly to combat this disease, which has had a significant impact on humanity. This study examines the effects of the COVID-19 pandemic on the performance of undergraduate healthcare students during internship, focusing on the leadership, social, and mental aspects.

Implementing Prehospital Ultrasound at the Saudi Red Crescent Authority: Perceived Barriers and Training Needs.

Objective: This study examines the inherent barriers to implementing prehospital ultrasound within the Saudi Red Crescent Authority (SRCA) in Saudi Arabia.

Methods: A qualitative study was conducted to explore the perceived barriers, mode of transportation, ultrasound familiarity, and self-efficacy level of relevant stakeholders in implementing the prehospital ultrasound in SRCA. Data was collected via surveys and interviews with 24 SRCA paramedics/EMTs, 4 SRCA station administrators, and two hospital physicians to further examine the inherent barriers of implementing the prehospital ultrasound.

The impact of body position on vital capacity among pregnant women in the second trimester.

Background: Pregnancy introduces significant physiological changes, notably impacting respiratory dynamics, especially during the second trimester. Data remain inconclusive about how body posture might influence lung function in pregnant women. We aimed to examine the impact of body position on slow vital capacity in pregnant women during their second trimester.

High potency of linalool-zinc oxide nanocomposite as a new agent for cystic echinococcosis treatment.

This current , , and research aims to evaluate and analyze the linalool-zinc oxide nanocomposite (Lin-ZNP) for treating cystic echinococcosis. Lin-ZNP was synthesized using an ethanolic solution of polyvinyl alcohol. The protoscolicidal effects of Lin-ZNP were tested on hydatid cyst protoscoleces (PTS) in both and by eosin exclusion test.

Health Care Clinical Preceptors' Attitudes Towards Interprofessional Education in Saudi Arabia: A Cross-Sectional Study.

Introduction: IPE fosters a dynamic learning environment that may promote students' knowledge, abilities, and collaborative approach towards addressing challenging clinical circumstances. While much has been reported in the literature regarding these diverse IPE learning environments, limited information exists regarding clinical preceptors' attitude and perceptions of IPE, especially in Saudi Arabia. Given the impact clinical preceptors have on the formation of healthcare students exploring their perceptions, which may impact their actions is imperative.

The Predictors and Risk Factors of 2-Year Rejection in Renal Transplant Patients: A Multicenter Case-Control Study.

Introduction: Kidney transplantation is a definitive treatment for end-stage renal disease. It is associated with improved life expectancy and quality of life. One of the most common complications following kidney transplantation is graft rejection.

Knowledge of Back Pain and Spinal Disorders Among the General Population in the Western Region of Saudi Arabia.

Introduction  Low back pain (LBP) is one of the most common global health problems and the second most common reason for seeking medical advice. However, most LBP does not indicate a serious disorder. Over half of the Saudi Arabian population experiences LBP at least once in their lives.

Mitoxantrone 2HCl's adroit activity against cervical cancer replication and maintenance proteins: a multitargeted approach.

Cervical cancer poses a significant global health challenge, ranking as the fourth most common cancer among women worldwide and resulting in approximately 300,000 deaths yearly, predominantly caused by high-risk human papillomavirus strains (HPV), mainly types 16 and 18. The scenario poses the urgent need of the hour to develop effective treatment strategies that can address the complexity of cervical cancer and multitargeted inhibitor designing that holds promise as it can simultaneously target multiple proteins and pathways involved in its progression and have the potential to enhance treatment efficacy, reduce the likelihood of drug resistance. In this study, we have performed multitargeted molecular docking of FDA-approved drugs against cervical cancer replication and maintenance proteins- Xenopus kinesin-like protein-2 (3KND), cell division cycle protein-20 (4N14), MCM2-histone complex (4UUZ) and MCM6 Minichromosome maintenance (2KLQ) with HTVS, SP and XP algorithms and have obtained the docking and MM\GBSA score ranging from -8.

Exploring the promising potential of noscapine for cancer and neurodegenerative disease therapy through inhibition of integrin-linked kinase-1.

Integrin-linked kinase (ILK), a β1-integrin cytoplasmic domain interacting protein, supports multi-protein complex formation. ILK-1 is involved in neurodegenerative diseases by promoting neuro-inflammation. On the other hand, its overexpression induces epithelial-mesenchymal transition (EMT), which is a major hallmark of cancer and activates various factors associated with a tumorigenic phenotype.

Managing High Frequency of Ambulance Calls in Hospitals: A Systematic Review.

Background: This study addresses the critical issue of high-volume emergency calls in hospitals, focusing on the strain caused by frequent caller patients on ambulance services. The aim was to synthesize various management methods for handling high-frequency hospital calls.

Methods: The systematic review was conducted following the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines and guided by the Cochrane Handbook for systematic reviews.

Retraction: Ruptured Isolated Common Iliac Artery Aneurysm Masquerading as Renal Colic.

[This retracts the article DOI: 10.7759/cureus.19752.