Transparency, trustworthiness and usefulness in pre-eclampsia randomised controlled trials in the last three decades.

Objectives: Over the last decades, there has been a rising number of randomised controlled trials (RCTs) on pre-eclampsia. We investigated pre-eclampsia RCTs between 1987 and 2021 and reported on trustworthiness, risk of biases, p-values, transparency, and usefulness.

Methods: We searched PubMed for RCTs containing "pre-eclampsia" or "hypertensive disorders of pregnancy" in the title between 1987 and 2021.

Early Diagnosis and Differences in Progression of Fetal Encephalocele.

In this case series, we present 3 cases of very early prenatal diagnosis of encephalocele that, despite similar appearances at diagnosis, had different disease progressions. Two of the cases were carried to term, whereas 1 resulted in a termination of pregnancy. The diagnoses were made via ultrasound examinations before cell-free DNA testing for chromosomal abnormality screening at 10 weeks' gestation, thereby highlighting the importance of performing a routine ultrasound examination before cell-free DNA testing antenatally.

The quality and utility of research in ectopic pregnancy in the last three decades: An analysis of the published literature.

Objective: Ectopic pregnancy is a potentially life-threatening health problem that affects fertility and generates a significant economic burden. Optimal management, including when to choose methotrexate, and whether to do salpingectomy or salpingostomy, is still unclear. This study aimed to assess the quality and utility of research on ectopic pregnancy in the last three decades.

Quality of evidence on pre-eclampsia in the last three decades: An analysis of published literature.

Objectives: In recent years, there has been an increasing amount of information published on pre-eclampsia. We analyzed trends in pre-eclampsia literature between 1997 and 2016 and reported on the quality and utility of randomized controlled trials (RCTs) between 1987 and 2016.

Methods: We searched PubMed for all articles containing "pre-eclampsia" or "hypertensive disorders of pregnancy" in the title between 1997 and 2016 for the general literature and between 1987 and 2016 for RCTs.