Publications by authors named "Alrun Hotz"

Article Synopsis
  • Keratosis palmoplantaris striata type I (SPPK-I) is a rare genetic skin condition marked by painful, thickened areas on palms and soles, often due to mutations in the desmoglein-1 gene.
  • Patients experience hyperkeratotic plaques and painful fissures, but existing treatments like salicylic vaseline and corticosteroids do not provide effective relief.
  • A case study highlights a specific genetic variant linked to SPPK-I, yet the search for effective treatments continues due to the limited options available for this disorder.*
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  • The study identified a new gene variant in NKPD1 linked to generalized lamellar ichthyosis among a family, enhancing the understanding of genetic factors in skin disorders.
  • This variant was confirmed to segregate with the disease in affected individuals, providing strong genetic evidence for its involvement.
  • Findings revealed NKPD1's potential role in skin lipid barrier formation and ceramide metabolism, differing from the previously known ASPRV1 association with autosomal dominant lamellar ichthyosis.
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  • Erythrokeratodermia variabilis (EKV) is a rare skin disorder marked by red patches and thickened skin plaques, usually inherited in an autosomal dominant pattern.
  • Traditionally, EKV was linked to mutations in connexin genes, but recent findings show other rare gene mutations can also cause the condition.
  • A study of seven patients with an EKV-like appearance found they had mutations linked to autosomal recessive congenital ichthyosis (ARCI), suggesting that ARCI should be considered when diagnosing EKV.
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Integrin α6β4, encoded by ITGA6 and ITGB4, is a transmembrane component of hemidesmosomes and plays an important role in connecting keratinocytes with extracellular matrix proteins. ITGB4 or ITGA6 biallelic pathogenic variants cause junctional epidermolysis bullosa (JEB) with pyloric atresia, which is associated with high lethality. Patients who survive usually develop JEB of intermediate severity and urorenal manifestations.

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Inherited ichthyoses are classified as Mendelian disorders of cornification (MEDOC), which are further defined on the basis of clinical and genetic features and can be divided into non-syndromic and syndromic forms. To date, mutations in more than 30 genes are known to result in various types of syndromic ichthyoses, which, in addition to mostly generalised scaling and hyperkeratosis of the skin, also show additional organ involvement. The syndromic ichthyoses are generally very rare and are classified based on the mode of inheritance, and can be further subdivided according to the predominant symptoms.

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Article Synopsis
  • Autosomal recessive congenital ichthyosis (ARCI) is a skin disorder characterized by abnormal scaling and has three main forms: lamellar ichthyosis, congenital ichthyosiform erythroderma, and harlequin ichthyosis.
  • The condition is caused by mutations in several genes, with the most severe form (harlequin ichthyosis) primarily linked to specific mutations in one gene, which can also lead to the other two forms.
  • A study involving 64 patients identified 34 novel mutations, expanding the known mutations associated with this condition and showing a connection between the type of mutation and the severity of the skin condition.
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Symptoms of obsessive-compulsive disorder (OCD) may rarely occur in the context of genetic syndromes. So far, an association between obsessive-compulsive symptoms (OCS) and ACTG1-associated Baraitser-Winter cerebrofrontofacial syndrome has not been described as yet. A thoroughly phenotyped patient with OCS and ACTG1-associated Baraitser-Winter cerebrofrontofacial syndrome is presented.

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Article Synopsis
  • Epidermolysis bullosa (EB) is a rare genetic skin disorder causing blisters to form on the skin and mucous membranes, with varying severity among patients.
  • A study conducted in Germany found an EB incidence of 45 cases per million live births, with higher rates for junctional EB compared to other countries, possibly due to better early genetic diagnosis.
  • With estimates of around 2000 EB patients in Germany, the findings aim to influence healthcare policies, drug development strategies, and support patient advocacy efforts for improved quality of life.
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In about 20-30% of all women with breast cancer, an increased number of cases of breast cancer can be observed in their family history. However, currently, only 5-10% of all breast cancer cases can be attributed to a pathogenic gene alteration. Molecular genetic diagnostics underwent enormous development within the last 10 years.

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Autosomal recessive Chanarin-Dorfman syndrome (CDS, MIM #275630) is defined as a neutral lipid storage disease with ichthyosis (NLSDI) due to an accumulation of lipid droplets in a variety of different tissues including liver and muscle cells, leucocytes, fibroblasts and nerve cells It is caused by biallelic mutations in the abhydrolase domain containing 5 gene (, MIM *604780) which is localized on the short arm of chromosome 3. Here we report an 18 month-old girl in whom we have identified the homozygous mutation c.700C > T, p.

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The autosomal recessive congenital ichthyoses (ARCI) are a nonsyndromic group of cornification disorders that includes lamellar ichthyosis, congenital ichthyosiform erythroderma, and harlequin ichthyosis. To date mutations in ten genes have been identified to cause ARCI: , , , , , , , , , and . The main focus of this report is the mutational spectrum of the genes and , which encode the epidermal lipoxygenases arachidonate 12-lipoxygenase, i.

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Many of the genetic childhood disorders leading to death in the perinatal period follow autosomal recessive inheritance and bear specific challenges for genetic counseling and prenatal diagnostics. Often, affected children die before a genetic diagnosis can be established, thereby precluding targeted carrier testing in parents and prenatal or preimplantation genetic diagnosis in further pregnancies. The clinical phenotype of congenital disorders of glycosylation (CDG) is very heterogeneous and ranges from relatively mild symptoms to severe multisystem dysfunction and even a fatal course.

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Autosomal recessive congenital ichthyosis (ARCI) belongs to a heterogeneous group of disorders of keratinization. To date, 10 genes have been identified to be causative for ARCI. NIPAL4 (Nipa-Like Domain-Containing 4) is the second most commonly mutated gene in ARCI.

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Autosomal recessive keratoderma-ichthyosis-deafness (ARKID) syndrome is a rare multisystem disorder caused by biallelic mutations in VPS33B; only three patients have been reported to date. ARKID syndrome is allelic to arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome (MIM #208085), a severe disorder with early lethality whose phenotypic characteristics also include ichthyosis, hearing loss, severe failure to thrive, platelet dysfunction and osteopenia. We report on an 11-year-old male patient with ARKID syndrome and compound heterozygous VPS33B mutations, one of which [c.

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Autosomal recessive congenital ichthyosis (ARCI) is a heterogeneous group of rare disorders of keratinization characterized by generalized abnormal scaling of the skin. Ten genes are currently known to be associated with ARCI: TGM1, ALOXE3, ALOX12B, NIPAL4 (ICHTHYIN), ABCA12, CYP4F22, PNPLA1, CERS3, SDR9C7, and SULT2B1. Over a period of 22 years, we have studied a large patient cohort from 770 families with a clinical diagnosis of ARCI.

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Autosomal recessive congenital ichthyosis (ARCI) represents a heterogeneous group of rare disorders of cornification with 3 major subtypes: harlequin ichthyosis (HI), lamellar ichthyosis (LI) and congenital ichthyosiform erythroderma (CIE). A 4th subtype has also been proposed: pleomorphic ichthyosis (PI), characterized by marked skin changes at birth and subsequently mild symptoms. In nationwide screenings of suspected cases of ARCI in Denmark and Sweden, we identified 132 patients (age range 0.

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Twenty-six families with keratinopathic ichthyoses (epidermolytic ichthyosis, superficial epidermolytic ichthyosis or congenital reticular ichthyosiform erythroderma) were studied. Epidermolytic ichthyosis is caused by mutations in the genes KRT1 or KRT10, mutations in the gene KRT2 lead to superficial epidermolytic ichthyosis, and congenital reticular ichthyosiform erythroderma is caused by frameshift mutations in the genes KRT10 or KRT1, which lead to the phenomenon of revertant mosaicism. In this study mutations were found in KRT1, KRT2 and KRT10, including 8 mutations that are novel pathogenic variants.

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5q14.3 deletions spanning and flanking MEF2C as well as intragenic MEF2C mutations have recently been described as a cause of severe intellectual disability, epilepsy, and muscular hypotonia, with variable brain and other anomalies. With an increasing number of patients described, the clinical presentation of the patients appears to be relatively uniform, however the structural brain phenotypes described are variable.

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