Publications by authors named "Alraies Z"
Immune cells experience large cell shape changes during environmental patrolling because of the physical constraints that they encounter while migrating through tissues. These cells can adapt to such deformation events using dedicated shape-sensing pathways. However, how shape sensing affects immune cell function is mostly unknown.
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- Cells in crowded environments use their nucleus to gauge spatial confinement, influencing behavior.
- When cells are confined, their nuclei deform, sending signals to increase contractility through specialized proteins.
- This "nuclear ruler" mechanism helps cells navigate tight spaces, playing a crucial role in processes like cancer invasion, immune function, and embryonic development.
The migration of immune cells can be guided by physical cues imposed by the environment, such as geometry, rigidity, or hydraulic resistance (HR). Neutrophils preferentially follow paths of least HR in vitro, a phenomenon known as barotaxis. The mechanisms and physiological relevance of barotaxis remain unclear.
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