Thyroid cancer and Hashimoto's thyroiditis in AUS/FLUS nodules: is there a correlation? A retrospective study.

Objectives: The global prevalence of Hashimoto's thyroiditis (HT) and differentiated thyroid cancer (DTC), particularly papillary thyroid cancer (PTC), is increasing. However, studies assessing correlations between these diseases have yielded inconsistent findings. Furthermore, patients diagnosed with HT show a higher prevalence of indeterminate cytology than those without HT.

infection and staple-line leak in patients with class III obesity undergoing laparoscopic sleeve gastrectomy: a retrospective study.

Objective: Globally, over 50% of the population is affected by , yet research on its prevalence and impact in patients with obesity undergoing laparoscopic sleeve gastrectomy (LSG) is inconclusive. This study aimed to assess the prevalence of infection in individuals with obesity undergoing LSG, evaluate the percentage of postoperative staple-line leaks, and explore the potential link between infection and staple-line leaks.

Methods: This retrospective analysis assessed adult patients with class III obesity who underwent LSG between 2015 and 2020 at a tertiary care hospital in Riyadh, Saudi Arabia.

Comparative Assessment of the Influence of Various Time Intervals upon the Linear Accuracy of Regular, Scannable, and Transparent Vinyl Polysiloxane-Based Bite Registration Materials for Indirect Dental Restoration Fabrication.

Interocclusal records (IORs) created with bite registration materials (BRMs) accurately reflect the opposing teeth's physiological and anatomical associations in digital and traditional dentistry. This study assessed the linear dimensional accuracy of vinyl polysiloxane-based scannable and transparent BRMs over obligatory clinical time intervals (1, 24, 72, and 168 h/s). A total of 3 scannable [Flexitime Bite, Occlufast CAD, Virtual CADBite] and 3 transparent [Maxill Bite, Charmflex Bite, Defend ClearBite] VPS-based BRMs were divided into 28 subgroups by time interval: 1, 24, 72, and 168 h/s.

A Comparative Analysis of Introvert and Extrovert Dental Students toward Clinical Performance.

Aim: This study aims to identify introvert and extrovert personality types among level-6 dental students in the College of Dentistry, Jazan University, Jazan, Saudi Arabia, and analyze their clinical performance.

Materials And Methods: In this causal-comparative research, 72 level-6 dental students (29 males and 43 females) of the College of Dentistry of Jazan University for the school year 2023-2024 were chosen to be the respondents. Myers-Briggs type indicator (MBTI), a personality test designed to differentiate introversion and extroversion, was used.

Microinvasive interventions in the management of proximal caries lesions in primary and permanent teeth- systematic review and meta-analysis.

Background: Dental caries is one of the most common non-communicable diseases in humans. Various interventions are available for the management, of which microinvasive techniques such as infiltration, sealants, glass ionomers, are novel and convenient. The purpose of this systematic review and meta-analysis was to compare microinvasive techniques with noninvasive or invasive treatment modalities in terms of effectiveness in halting interproximal caries lesion progression radiographically assessed.

Awareness and Knowledge of Developmental Coordination Disorder Among Healthcare Professionals in the Eastern Province of Saudi Arabia: A Cross-Sectional Study.

Developmental coordination disorder (DCD) is a lifelong neurological disorder impairing the coordination and planning of motor and sensory tasks. Its functional manifestation includes difficulties in various aspects of daily living, making early diagnosis and management essential. This cross-sectional, questionnaire-based study targeted healthcare providers in Saudi Arabia's Eastern Province who work with children under the age of 18.

Dimensional Accuracy of Intraoral Scanners in Recording Digital Impressions of Post and Core Preparations: A Systematic Review.

Background: This study aims to perform a review by selecting, analyzing, and evaluating articles that discuss the accuracy of intraoral scanners (IOSs) in recording post space compared to conventional impression-making techniques.

Methods: The review question framed using the PITR framework (participant, index test, targeted condition, and reference standard) is as follows: What is the dimensional accuracy (T) of impressions made using intraoral scanners (I) for post space (P) compared to impressions made using conventional techniques and digitalized using extraoral scanners (R)? Four electronic databases were searched using pre-set keywords. The guidelines and strategies recommended by PRISMA formed the basis for planning, executing, and documenting this systematic review.

Infants of diabetic mothers: epidemiology, pathophysiology, fetal heartassessment, structural and functional heart consequences: A narrative review.

Infants of diabetic mothers are neonates born to a woman who had periodic hyperglycaemia during pregnancy. Consequently, infants of diabetic mothers are at higher risks of illness besides morbidity and mortality due to teratogenic effects on the fetal cardiovascular system, causing most frequent CHDs. The primary purpose of this review is to present, on this topic, a better-comprehended review covering pertinent material and data to be informed of severe risks to a newborn's cardiac system and function.

Evaluation of the relationship between infected gastric mucosa and prognosis of gastrointestinal stromal tumor.

Objective: Gastrointestinal stromal tumor (GIST) is the most common type of mesenchymal tumor accounting for 2.2% of all malignant gastric tumors. Mesenchymal stem cells (MSCs) play crucial roles in gastric carcinogenesis.

Awareness of Obesity and Weight Loss Management Among Adults in the Asir Region, Saudi Arabia.

Obesity, a chronic disease marked by excessive fat accumulation and a body mass index (BMI) of 30 kg/m² or more, has become a major global health issue, affecting many adults worldwide and particularly prevalent in developed nations and Saudi Arabia. The condition can be caused by genetic, metabolic, and lifestyle factors. Understanding its awareness is imperative in designing effective health interventions.

Coexistence of Hodgkin Lymphoma and Squamous Cell Carcinoma of the Tongue: A Case Report and Literature Review.

We report an unusual case of a 39-year-old male patient with a previous history of treated classical Hodgkin lymphoma, presenting with tongue ulcer and left ear pain who was subsequently diagnosed with invasive squamous cell carcinoma of the oropharynx. This case highlights the importance of vigilance in patients with a history of lymphoma and the potential for the development of secondary malignancies. We discuss the clinical, radiological, and pathological findings and emphasize the need for close monitoring and early intervention in such cases.

A novel numerical solution of nonlinear stochastic model for the propagation of malicious codes in Wireless Sensor Networks using a high order spectral collocation technique.

The open nature of Wireless Sensor Networks (WSNs) renders them an easy target to malicious code propagation, posing a significant and persistent threat to their security. Various mathematical models have been studied in recent literature for understanding the dynamics and control of the propagation of malicious codes in WSNs. However, due to the inherent randomness and uncertainty present in WSNs, stochastic modeling approach is essential for a comprehensive understanding of the propagation of malicious codes in WSNs.

MicroRNAs and long non-coding RNAs In T-cell lymphoma: Mechanisms, pathway, therapeutic opportunities.

T-cell lymphomas represent non-Hodgkin lymphomas distinguished by the uncontrolled proliferation of malignant T lymphocytes. Classifying these neoplasms and the ongoing investigation of their underlying biological mechanisms remains challenging. Significant subtypes encompass peripheral T-cell lymphomas, anaplastic large-cell lymphomas, cutaneous T-cell lymphomas, and adult T-cell leukemia/lymphoma.

Stress hyperglycaemia ratio is an independent predictor of in-hospital heart failure among patients with anterior ST-segment elevation myocardial infarction.

Background: Stress hyperglycaemia ratio (SHR) has been reported to be independently and significantly associated with various adverse cardiovascular events as well as mortality. Moreover, in-hospital heart failure following acute myocardial infarction has been demonstrated to account for majority of all heart failure (HF) cases with anterior myocardial infarction showing higher rates of HF. However, the association between SHR and in-hospital HF following an anterior ST-elevation myocardial infarction (STEMI) has not been reported earlier.

The impact of patient support and health education on diabetes management and glycemic control.

Diabetes mellitus is a chronic and complex medical condition that can lead to significant morbidity and mortality. Maintaining an adequate blood glucose level is important for patients with diabetes, and to improve glycemic control, patients need proper support and health education, which are essential components of comprehensive diabetes care. We used a rigorous approach based on the PRISMA and Cochrane Handbook principles, specifically focusing on randomized controlled trials (RCTs) published in English from 2005 onwards.

Characteristics and outcomes of patients with Guillain-Barré syndrome who were admitted to the intensive care unit: a retrospective observational study.

Objective: To evaluate characteristics and outcomes in critically ill patients with Guillain-Barré syndrome (GBS).

Methods: Consecutive adults with GBS who required intensive care unit (ICU) admission at a tertiary-care hospital between 1999 and 2020 were enrolled into this retrospective cohort study. Demographics, clinical data and patient outcomes were compared between patients who did or did not receive mechanical ventilation (MV).

Clinical and epidemiological characteristics of respiratory syncytial virus, SARS-CoV-2 and influenza paediatric viral respiratory infections in southwest Saudi Arabia.

Background: There is a global consensus that respiratory tract infections are the major causes of morbidity and mortality among children. In this study, we aimed to compare the clinical and epidemiological characteristics of respiratory syncytial virus (RSV), influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among children admitted to hospital with acute respiratory infections. We also opted to identify the predictors of paediatric intensive care unit (PICU) admission.

Budget impact analysis of baricitinib for treatment of alopecia areata: A Saudi hospital perspective.

Objectives: To perform a budget impact analysis (BIA) of the adoption of baricitinib for the management of alopecia areata (AA) by a Saudi public sector payer.

Methods: A BIA model was developed to calculate the expected financial impact under two scenarios: the baseline scenario, which reflects the current mix of treatments without baricitinib, and the projected scenario, in which baricitinib is adopted. The model assumed that patients with severe AA and those with mild-to-moderate AA who did not respond to other treatments were eligible for baricitinib treatment.

The clinical utility of shock index in hospitalised patients requiring activation of the rapid response team.

Background: The systolic shock index (SSI) is used to direct management and predict outcomes, but its utility in patients requiring rapid response team (RRT) activation is unclear.

Objectives: We explored whether SSI can predict the outcomes of ward patients experiencing clinical deterioration and compared its performance with other parameters.

Methods: This retrospective study included adult patients in medical/surgical wards who required RRT activation.

Derivative Technologies of Expansion Microscopy and Applications in Biomedicine.

Expansion microscopy (ExM) is an innovative super-resolution imaging technique that utilizes physical expansion to magnify biological samples, facilitating the visualization of cellular structures that are challenging to observe using traditional optical microscopes. The fundamental principle of ExM revolves around employing a specialized hydrogel to uniformly expand biological samples, thereby achieving super-resolution imaging under conventional optical imaging conditions. This technology finds application not only in various biological samples such as cells and tissue sections, but also enables super-resolution imaging of large biological molecules including proteins, nucleic acids, and metabolite molecules.

Predictors of liver fibrosis progression in cohort of type 2 diabetes mellitus patients with MASLD.

Aim: To investigate predictors of liver fibrosis progression in patients with type 2 diabetes mellitus (T2DM) over a minimum follow-up duration of three years.

Methods: Two hundred and thirty-three patients completed the follow-up period and their clinical, laboratory and liver FibroScan data are reported. Patients were categorized into progressors 42 (18.

A comprehensive evaluation of safety and awareness in eyebrow microblading: a cross-sectional study.

The importance of eyebrows in facial aesthetics has long been recognized, and eyebrows restoration is carried out by carefully depositing pigments into the epidermis. This cosmetic procedure is known as microblading, and it is very popular because of the progress made on social media platforms. This study was designed to determine the awareness of eyebrow microblading, complication and laser removal in general population of Saudi Arabia.

A bibliometric analysis of inflammatory bowel disease research in the Arab world.

Background: The prevalence of inflammatory bowel disease (IBD) continues to increase worldwide, including in the Arab world. This study investigates IBD research output in Arab countries from 2009 to 2023, alongside prevalence and incidence trends.

Methods: We utilized bibliometric analysis with data from Clarivate Analytics, the Institute for Health Metrics and Evaluation, and the World Bank.

Electronic Sepsis Screening Among Patients Admitted to Hospital Wards: A Stepped-Wedge Cluster Randomized Trial.

Importance: Sepsis screening is recommended among hospitalized patients but is supported by limited evidence of effectiveness.

Objective: To evaluate the effect of electronic sepsis screening, compared with no screening, on mortality among hospitalized ward patients.

Design, Setting, And Participants: In a stepped-wedge, cluster randomized trial at 5 hospitals in Saudi Arabia, 45 wards (clusters) were randomized into 9 sequences, 5 wards each, to have sepsis screening implemented at 2-month periods.

Post-thyroidectomy hypoparathyroidism: A clinical surgical dilemma.

Thyroid dysfunction directly affects human health and overall well-being; various approaches are available for the treatment of thyroid diseases, including conservative measures and surgical interventions. Despite advancements in conservative treatment, surgery remains the preferred option. Hypoparathyroidism is the primary cause of hospitalization after thyroidectomy, leading to cost-related concerns and a detrimental impact on patients' overall quality of life.