Publications by authors named "Alpha Fowler Iii"
Article Synopsis
- A Phase II clinical trial examined the effects of intravenous vitamin C on patients receiving hematopoietic stem cell transplants to reduce nonrelapse mortality (NRM).
- Patients (55 total) were given IV vitamin C for 14 days, which corrected their initial vitamin C deficiency and showed a trend towards lower NRM (11%) compared to historical controls (25%).
- The study suggests that vitamin C repletion is safe and may improve survival rates (82% vs. 62%), but further randomized trials are necessary to validate these findings.
We report a case of virus-induced acute respiratory distress syndrome (ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection. From very significant preclinical research performed at Virginia Commonwealth University with vitamin C and with the very positive results of a previously performed phase I safety trial infusing high dose vitamin C intravenously into patients with severe sepsis, we reasoned that infusing identical dosing to a patient with ARDS from viral infection would be therapeutic.
View Article and Find Full Text PDFImpact of high dose vitamin C on platelet function.
World J Crit Care Med
February 2017
Aim: To examine the effect of high doses of vitamin C (VitC) on human platelets (PLTs).
Methods: Platelet concentrates collected for therapeutic or prophylactic transfusions were exposed to: (1) normal saline (control); (2) 0.3 mmol/L VitC (Lo VitC); or (3) 3 mmol/L VitC (Hi VitC, final concentrations) and stored appropriately.