Neurofibromatosis type 2 in the elderly population: clinical and molecular features.

Neurofibromatosis type 2 (NF2) is rare genetic disorder characterized by the development of multiple benign tumors of the nervous system. The majority of people with NF2 are diagnosed in the second or third decade of life with bilateral vestibular schwannomas. Among NF2 patients followed up in our NF2 clinic, seven patients have been diagnosed with NF2 after the age of 70 years.

Long-term follow-up of 287 meningiomas in neurofibromatosis type 2 patients: clinical, radiological, and molecular features.

Decision-making criteria for optimal management of meningiomas in neurofibromatosis type 2 (NF2) patients is hampered by lack of robust data, particularly long-term natural history. Seventy-four NF2 patients harboring 287 cranial meningiomas followed up for a mean period of 110.2 months were studied retrospectively.

Differential MRI analysis for quantification of low grade glioma growth.

A differential analysis framework of longitudinal FLAIR MRI volumes is proposed, based on non-linear gray value mapping, to quantify low-grade glioma growth. First, MRI volumes were mapped to a common range of gray levels via a midway-based histogram mapping. This mapping enabled direct comparison of MRI data and computation of difference maps.