Publications by authors named "Alper Sevımlı"

Cells obtained from chicken embryos are often preferred for in vitro studies. These cells, which easily adapt to rapid and continuous growth in the appropriate cell culture environment, are thought to be one of the effective methods in the investigation of leg diseases that are frequently observed in poultry. Leg diseases, especially affecting the joints in chickens, cause locomotor problems and adversely affect animal welfare.

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Gabapentinoids are effective adjunct drugs for reducing postoperative pain. However, the effects of gabapentinoids on wound healing have not been evaluated yet. In this study we evaluated their effects on wound healing.

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Article Synopsis
  • The study examined the effects of intra-articular dexketoprofen trometamol on rabbits, focusing on histopathological and biochemical changes.
  • A total of 24 New Zealand rabbits were divided into a control group (saline injections) and a treatment group (dexketoprofen trometamol injections), with samples collected over various days.
  • The results showed no significant deterioration in histopathological examinations, although some biochemical markers (IL-6, TNF-α, CRP) increased in the treatment group; these changes were not deemed clinically significant.
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The aim of this study is to evaluate the effects of intra-articular levobupivacaine on rabbit knee articular cartilage and certain biochemical parameters in the blood. A total of 24 New Zealand rabbits were included to study. Blood sampling was carried out in all animals on the first day, then the subjects were randomly allocated either to the control group (Group C, n = 9) or to the levobupivacaine group (Group L, n = 15).

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Cyclosporine A (CsA) is a drug used in autoimmune disorders and organ transplantations. Omega 3 fatty acids (O-3) and sesame oil (SO) have antioxidant properties. We aimed to investigate and compare the protective effects of O-3 and SO against CsA-induced nephrotoxicity.

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Background: Increased proteolytic cleavage of serum amyloid A (SAA) may potentially contribute to the development of AA amyloid deposition.

Objective: To study the possible relationship between amyloid artropathy and expression of SAA and some serum amino acids.

Animals And Methods: Values of 15 serum amino acids and SAA were investigated in chickens with experimentally induced amyloid arthropathy.

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This study was designed to determine the acute effects of a single-dose of orally administered doramectin, eprinomectin and selamectin on Syphacia muris infection in rats. Rats, naturally infected with S. muris, were divided into four groups: three different treatment groups (n=7) and one positive control (n=7).

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Article Synopsis
  • The study explored the impact of cytokines IL-1beta, IL-6, and TNF-alpha in chickens affected by amyloid arthropathy, focusing on varying levels of amyloid accumulation.
  • A total of 100 chickens were divided into four groups, with specific treatments (like Vitamin A and methylprednisolone) administered to influence amyloidosis severity after inducing it with Freund's adjuvant.
  • Results indicated a strong correlation between amyloidosis severity, amyloid levels, and IL-1beta, while higher TNF-alpha levels were linked to increased amyloidosis severity, suggesting IL-1beta’s significant role in this condition.
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Clinical, blood, serum biochemistry, and parasitological assessments were performed on four hospitalized dogs, not in good general condition, in a study carried out to determine the prevalence of general parasitic infections. Hematological and biochemical parameters and electrocardiographic recording of the animals were determined during the general clinical examinations. Four dogs were indicated to have been infected with Dirofilaria immitis by using modified Knott's method, and the microfilarial density was determined.

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The effects of vitamin A, pentoxyfylline and methylprednisolone on experimentally induced amyloid arthropathy were investigated. In this study, 175 1-day-old brown layer chicks were used. Throughout the study Group II (vitamin A) received high doses of vitamin A (75,000 IU/kg), whereas Group I (negative control), Group III (positive control), Group IV (pentoxyfylline) and Group V (methylprednisolone) received normal levels of vitamin A in the diet.

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