Publications by authors named "Alper Ertugrul"
Purpose: Hydroxychloroquine (HCQ) is used in the treatment of several diseases, such as malaria, Sjögren's disease, Covid-19, and rheumatoid arthritis. However, HCQ induces retinal pigment epithelium death via the excessive increase of cytosolic (cROS) and mitochondrial (mROS) free oxygen radical production. The transient receptor potential melastatin 2 (TRPM2) cation channel is stimulated by ADP-ribose (ADPR), cROS, and mROS, although it is inhibited by curcumin (CRC).
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- - The study aimed to assess the effectiveness of adalimumab (ADA) in preventing corneal neovascularization (CNV) and to compare its results with those of bevacizumab (BEVA) in a rat model.
- - Twenty-four female Winstar rats were divided into six groups, receiving different treatments, with evaluations occurring five days post-treatment using various staining techniques to analyze histopathological changes.
- - Results indicated that both ADA and BEVA were successful in reducing CNV, but ADA was found to be more effective than BEVA in reducing vascular endothelial growth factor (VEGF) expression, highlighting the need for further research on these treatments.