Objective psychological measurement and clinical assessment of anxiety in adverse drug reactions.

Background: A confounding factor in the diagnosis of adverse drug reactions (ADRs) is the psychological state of the patient. Patients with underlying anxiety and related disorders may present with psychogenic reactions, which involve physiologic responses originating from psychological, rather than organic factors.

Objective: To examine the contribution of anxiety and related disorders to adverse drug events.

Mechanism of Impila (Callilepis laureola)-induced cytotoxicity in Hep G2 cells.

Objectives: To determine the mechanism(s) of Impila (Callilepis laureola)-induced toxicity in human hepatoblastoma Hep G2 cells in vitro and the possible prevention of this toxicity by N-acetylcysteine (NAC).

Design And Methods: Cells were treated with an aqueous extract of Impila (10 mg/mL) for up to 24 h. NAC (5 mM) was administered either concomitantly with Impila or one hour post Impila treatment.