Publications by authors named "Alpa Kanji"
Children with severe atopic dermatitis (AD), refractory to conventional systemic treatment as well as single-agent biologic and Janus kinase inhibitor (JAKi) such as abrocitinib, currently face a lack of treatment options. In response to this clinical conundrum, we present three cases of severe and refractory pediatric AD successfully managed with combined dupilumab and abrocitinib. These children had exhausted all conventional treatments and had undergone treatment with both dupilumab and abrocitinib individually, as well as dupilumab in conjunction with methotrexate.
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- Post-transplant lymphoproliferative disorders (PTLD) can occur in organ transplant recipients due to immunosuppression, often manifesting in various organs, including rarely as skin ulcers.
- A case study highlights a 36-year-old male cardiac transplant patient who developed a painless ulcer on his leg, which was diagnosed as a monomorphic B-cell PTLD via biopsy and imaging techniques.
- Treatment involved stopping one immunosuppressive medication and administering rituximab, resulting in ulcer resolution and no current disease recurrence, emphasizing the importance of recognizing and promptly treating PTLD to prevent serious complications.
CD34-positive dermal fibromas (PDFs) are cutaneous neoplasms that display a characteristic pattern of superficial dermal spindle cell proliferation on histopathology evaluation. They are clinically heterogenous in presentation and thought to follow a benign course. CD34-PDFs have features that overlap with dermatofibrosarcoma protuberans (DFSP), a locally aggressive low-grade superficial sarcoma.
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- - The study analyzed 42 psoriasis patients who completed narrowband ultraviolet B phototherapy from January 2016 to August 2018, focusing on the potential implementation of a patient-initiated follow-up (PIFU) pathway.
- - If a PIFU pathway had been in place, 24 routine follow-up appointments could have been avoided, and 8 nonattendances prevented, highlighting the demand for easier access to care for those who relapse after treatment.
- - Results showed that 50% of patients relapsed within 36 months, with most relapses happening in the first year, suggesting a 12-month PIFU period could efficiently support patients post-therapy and reduce unnecessary follow-ups.
Campylobacter jejuni is the leading cause of foodborne bacterial gastroenteritis worldwide. Although the mechanisms by which C. jejuni causes disease are not completely understood, the presence of functional flagella appears to be required for colonisation of the gastrointestinal tract of humans and animals.
View Article and Find Full Text PDFQuantitative RNA-seq analysis of the Campylobacter jejuni transcriptome.
Microbiology (Reading)
October 2011
Campylobacter jejuni is the most common bacterial cause of foodborne disease in the developed world. Its general physiology and biochemistry, as well as the mechanisms enabling it to colonize and cause disease in various hosts, are not well understood, and new approaches are required to understand its basic biology. High-throughput sequencing technologies provide unprecedented opportunities for functional genomic research.
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