Publications by authors named "Alp Tokalioglu"
Introduction: We aimed to demonstrate the sensitivity of frozen section for patients with adult granulosa cell tumor (AGCT) and analyze the clinico-pathological factors that may be associated with sensitivity.
Material Methods: This is a multicenter study including data of 10 Gynecological Oncology Departments. Frozen-section results of patients who had ovarian AGCT at the final pathology report were retrospectively analyzed.
Objective: We aimed to investigate differences between HPV-16 mono- and HPV-16/18 co-infections in terms of cervical dysplasia and invasive cancer.
Methods: This multicentre, retrospective study spanned from December 2017 to December 2020, involving women who visited gynaecological oncology clinics for colposcopy with either HPV-16 or HPV-16/18 positivity. A total of 736 patients, 670 in Group 1 (HPV-16 positivity) and 66 in Group 2 (HPV-16/18 positivity), were compared for the presence of CIN2+ lesions detected by colposcopic biopsy or endocervical curettage (ECC).
Objective: To define the clinical, histopathological features and the prognostic factors affecting survival in patients with adult granulosa cell tumors of the ovary (AGCT).
Methods: A 322 patients whose final pathologic outcome was AGCT treated at nine tertiary oncology centers between 1988 and 2021 participated in the study.
Results: The mean age of the patients was 51.
Article Synopsis
- The study investigates clinical, surgical, and pathological factors in patients with stage 1C adult granulosa cell tumors (AGCT), focusing on the role of adjuvant therapy in recurrence and survival rates.
- Out of 415 patients treated, 63 met the criteria for stage 1C AGCT, and comparisons were made between those receiving adjuvant chemotherapy and those who did not, measuring disease-free survival (DFS) outcomes.
- Findings showed that adjuvant chemotherapy did not significantly affect DFS or overall survival, indicating a need for further multicentric and randomized studies to validate these conclusions.